Review of "some of the big science stories of the past 12 months" and the "dub[bing of] one of them the Breakthrough of the Year." Features a description of the Breakthrough of the Year (the solution of the Poincaré Conjecture, a century-old mathematics problem) and the runners-up in areas such as paleogenomics, glaciology, paleontology, optics, medicine, evolutionary biology, neuroscience, and molecular biology. Also includes material about scientific fraud. Requires free registration. From Science magazine.