Acetaminophen Synthesis Lab Report
Purpose The aim of this experiment is to an amide is created by treating an amine with acid anhydride during acetaminophen preparation. Acetaminophen (p-acetamidophenol), the amide, is produced when the amine p-aminophenol is subjected to treatment by acetic anhydride. Experiment Data/Results We started this experiment by obtaining a 50 mL Erlenmeyer flask so we are able to transfer the compounds needed for this reaction mixture. We weighed about 1.5008 grams of p-aminophenol and placed this directly into the Erlenmeyer flask. By using a graduated cylinder, we obtained 4.5 mL of water and 1.7 mL of acetic anhydride, followed by the addition of a magnetic stir bar into our Erlenmeyer flask. Once we have all the components we need in the …show more content…
It can be administered to patients with mild to moderate pain by itself or in conjunction with an opioid analgesic for severe pain. The mechanism of …show more content…
We added a magnetic stir bar to mix the components thoroughly for the next step of heating them. Since this mixture is a reaction mixture we are going to use a hot plate to heat up the reaction mixture at about 90 ℃. The reason why we are using this temperature range is due to the fact of p-aminophenol has a boiling point of 284 ℃. We only need a certain amount of heat to keep the p-aminophenol and force the mixture to react with the heat, the best temperature range is 90-100 ℃ for this reaction mixture. We observed the reaction mixture temperature carefully by using a thermometer so the temperature does not go lower or higher than the desired temperature range. If this were to happen, the reaction mixture would produce a completely different reaction or a certain component would have been missing (dissolved) within the reaction mixture. Throughout the heating process, we observed the solid being dissolved, precipitated, and, redissolved. This was able to happen because paracetamol and acetic acid are the byproducts of the primary reaction that occurs when p-aminophenol and acetic anhydride react. This response is completed in three unique solvents; iso-amyl alcohol, water, and 2-propanol. In addition, the reaction can be carried out with or without impurities. The hydrolysis reaction between acetic anhydride and water produces H+ when water is
Acetaminophen Research Paper
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Commercial Asa Synthesis Lab Report
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Chemical Reactions Lab Report
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Hydrolysis Of T-Butyl Chloride Lab Report
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Phosphoric Acid And Acetylsalicylic Acid Lab Report
2007 Words | 9 Pages3mL of strong smelling, clear colorless acetic anhydride liquid was then measured in a 10mL graduated cylinder in the fume hood, and poured into the Erlenmeyer flask. The flask was then gently swirled while 5 drops of 85% phosphoric acid was added to the flask. During this time, the solution in the flask was whitish and cloudy. Phosphoric acid was used in the synthesis to become a source of H+ ions that would catalyze the reaction. Phosphoric acid is a liquid that doesn 't contain much water, since water will cause side reactions and reduce the yield of acetylsalicylic acid.
Preparation Of L-Phenylalanine Lab Report
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Acetonitrile Lab Report
1692 Words | 7 Pages2.2 Chemicals and reagents The API of AN (99.9% pure) 1000mg was purchased from market. HPLC grade acetonitrile (SD fine limited). Analytical grade hydrochloric acid ,sodium hydroxide flakes, hydrogen peroxide. Milli-Q Water purchased from market.. 2.3 Details of Method Chromatographic conditions: Reversed Phase High Performance liquid chromatography method with UV detection separation was achieved on zorbox Agilent Eclipsc XDB column c18(150 nm× 4.6 mm×5µm) as stationary phase with binary gradient mode solvent phase A. Composed of H3PO4(ortho phosphoric acid ) buffer ( pH ≈2, 0.02M) and phase B as Acetonitrile ,The Flow rate of the mobile phase was 1.0 mL/min and the total elution time including the column re-equilibration was approximately
Phenacetin Synthesis
424 Words | 2 PagesThe main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.
Diels Alder Reaction Lab
672 Words | 3 PagesThe formation of two products is not ideal but luckily easy to separate. In order to separate the major product from the minor product, the addition of cold xylene is used. The minor product and the reactants are soluble in cold xylene, but the major product is insoluble. Washing the product with cold xylene than will result in a rather pure product.
Aspirin Synthesis Lab Report
1863 Words | 8 PagesIntroduction Due to its affordability and effectiveness, acetylsalicylic acid, or Aspirin, is a widely popular over-the-counter medication2. Part of a medication class called ‘NSAID’s (non-steroid anti-inflammatory drugs), aspirin is commonly used in the treatment of simple inflammatory ailments such as headaches and low-grade fevers2. The synthesis of aspirin is relatively simple. The two reactants are acetic anhydride and salicylic acid and the products are acetylsalicylic acid and acetic acid1.
Tenofovir4 Case Study
1833 Words | 8 PagesFiltered the solution through 0.45 µm nylon filter Buffer having pH 3.70 used as Mobile phase A and mixture of methanol, acetonitrile and tetrahydrofuran (50: 50: 2 v/v/v) were used as Mobile phase B. Diluent: Prepared a mixture of buffer and methanol (80: 20 v/v). Placebo preparation (Placebo I): Weighed accurately and transferred 255 mg of placebo to a 100 mL volumetric flask. Add 40 mL of methanol and sonicated for 10 mins and add about 30 mL of diluent and again sonicate for 15 mins. Allow to equilibrate at room temperature (RT) and dilute to volume with diluent.
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893 Words | 4 PagesThe reactions between acids and bases of solutions are extremely important in a number of different contexts such as industrial, environmental, and biological. Acid reflux is common in many people and it causes heartburn; Antacids help temporarily alleviate this. This investigation helps
Aspirin Lab Report
1524 Words | 7 PagesThe hydrolysis formed salicylic concentration which was mixed with iron(III) solution to form a purple complex. This was then use to study under the UV/Visible absorption spectroscopy which gave absorbance values recorded at 525nm to determine the concentration of salicylic acid using the Beer Lambert’s Law and later corrected to find the actual concentrations. The concentrations of aspirin at various intervals was found from salicylic concentrations. Upon plotting a graph of ln(aspirin) vs time, it produced a linear equation from which the gradient gave the rate constant of 0.0083min-1 and the overall shape of the graph concluding this reaction to be pseudo first order with respect to the concentration of aspirin with the deviations and improvements as
Synthesis Of Aspirin
822 Words | 4 PagesAspirin is synthesized through three different steps, the synthesis of the aspirin, the isolation and the purification and finally the purity estimation of the final product. It involves the reaction of acetic anhydride and salicylic acid in the presence of phosphoric acid = H3PO4. After the aspirin is synthesised it then mist be isolated form the reaction solution and purified. This procedure is a possible experiment to execute at a
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