ABSTRACT:
Pantoprazole sodium is an antiulcer drug. This compound inhibits gastric acid formation and thereby it is very efficient for the treatment of gastric and duodenum ulcers. But pantoprazole sodium is acid labile drug that will degrade in acidic environment of stomach resulting in therapeutic inefficacy. Hence it is necessary to bypass the acidic pH of the stomach which can be achieved by formulating delayed release dosage forms (single unit or multiple units) by using different enteric polymers
The present study was an attempt to formulate and evaluate enteric coated tablets for pantoprazole sodium sesquihydrate. Different core tablets were prepared using different superdisintegrants (Sodium starch glycolate, croscarmellose sodium,
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Finally, magnesium stearate (passed through a 60-mesh/250 micron screen) was introduced to the powder mixture. The final mixture was shaken manually for 5-10 min in a plastic bag. This powder was passed through the hopper of 16 station rotary tabletting machine and punched into tablets using 8mm s/c. the process is similar for all core formulations, which are prepared by direct compression technique.
FORMULATION OF ENTERIC COATED TABLETS OF PANTOPRAZOLE SODIUM
Formulation design:
Pantoprazole enteric coated tablets were prepared using different polymers like HPMC 5cps (sub coat) AQOAT, CAP and KOLLICOAT MAE 30DP.
Different formulations of pantoprazole sodium enteric coated tablets were prepared using the polymers in different ratios keeping core tablet (C3) constant. They are assigned with formulation codes.
GENERAL FORMULATION
A formula is set using following ingredients:
Coating polymer - HPMC 5cps, CAP, AQOAT, KOLLICOAT MAE30DP
Solvent - Isopropyl alcohol, Dichloromethane, Water
Plasticizer - Triethyl
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Figure 15: FTIR spectra of pantoprazole sodium+kollicoat MAE 30DP
Drug-excipient compatability studies: FTIR
In the FTIR spectra of pure drug and different polymers it is observed that the peaks of major functional groups which are present in spectrum of pure drug are observed in combination of drug and polymers. There was no appearance or disappearance of any characteristics peak in the FTIR spectrum of Optimized formulation. This shows that there is no chemical interaction between the drug and the polymers used .The presence of peaks at the expected range confirms that the materials taken for the study are genuine and there were no possible interactions occurred.
7.1.2 PREFORMULATION CHARACTERISTICS
Table 23: Preformulation of powder blend of pantoprazole sodium core tablet
Formulation code Angle of repose Bulk density
(gm/cm2) Tapped density (gm/cm2) Hausners ratio %compressibility C1 25.7±0.03 0.34±0.02 0.42±0.03 1.24 19.04±0.01 C2 26.8±0.01 0.36±0.02 0.45±0.05 1.26
It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl
The difference in this chemical and physical properties will aid in their separation. Processes like solubility, gravitational filtration and recrystallization will be used to separate the substances present in Panacetin. The melting and boiling point of the substances will help in concluding on which of these compounds will be presented at the end of experiment. Procedure and observation The Panacetin content was weighed approximately 3.0493g and transferred to the Erlenmeyer flask; 75ml of dichloromethane (CH¬2CL2) was added to the content. The dichloromethane (CH2Cl2) dissolved the sucrose, leaving the active unknown agent and aspirin behind.
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People use many different kinds of biomedical interventions in the instance of stomach discomfort, mostly antacids but in some cases H-2 receptor antagonists, and pro-kinetics. There are a few different antacids out there including: Pepto-Bismol, Alka-Seltzer and Tums. The most common H-2 receptor antagonist is Pepcid and pro-kinetics is the least common route to relief. Pepto-Bismol is one of the more common interventions to defeating dyspepsia and is offered as a liquid, caplet and chewable tablet. It’s active ingredient is bismuth subsalicylate and does many things in order to relieve the stomach of pain.
Poop pills have to be made freshly so they don't dissolve in time. The diseases that these kill can kill 14 million
Today, atrazine is one of the most commonly used herbicides in the United States. It is used mainly on corn to control the growth of annual broadleaf and grassy weeds. Atrazine inhibits photosynthesis in plants by preventing electron transfer at the reducing site of photosynthesis complex II in chloroplasts, making it an effective herbicide. Atrazine is persistent in the environment, having a half-life of greater than 100 days in surface water [12]. It is the most commonly detected pesticide in surface and ground waters.
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