There are many reasons a once great man may fall. Hubris leads Macbeth into taking far too courageous actions, his lack of questioning makes him blind, and his own actions lay the blame of the Murder solely on his shoulders. While most can agree Lady Macbeth had her part in persuading him, one cannot blame her for the act simply because she wanted it to happen. Macbeth is the murderer, his wife didn't make one.
Macbeth is firstly at fault due to his own hubris. From the start of the play we hear praise for Macbeth from the captain when he addresses Duncan, “For brave Macbeth—well he deserves that name—Disdaining fortune, with his brandished steel,Which smoked with bloody execution,Like valor’s minion carved out his passage” (1.2.16-19), this sort of praise was likely commonplace after the battle, and likely was heard by macbeth himself, and being the proud man he was may have led him to feel deserving of greater power and authority. Another way his hubris is to blame is for being convinced by his wife's scorning oh his manhood should he not kill duncan “When you durst do it, then you were a man; And to be more than what
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He chose to kill Duncan when speaking to his wife “I am settled, and bend up Each corporal agent to this terrible feat. Away, and mock the time with fairest show. False face must hide what the false heart doth know.” (1.7.79-82) He has decided not only to kill his king, but to pretend that he is innocent, and take his throne, It is his decision, not Lady Macbeth’s. Even Macbeth himself accepts responsibility for the act, “I’ll go no more: I am afraid to think what I have done; Look on't again I dare not.” (2.2.51-53) Despite the fact that he is convinced he is taking the right course of action, directly following the act he regrets it. He does not blame Lady Macbeth for he knows he is to blame, and she is forced metaphorically clean up his mess by making a mess of the