Acetaminophen Synthesis Lab Report

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Objectives The objective of this experiment is to perform Quality Control (QC) tests to assess if the Acetaminophen sample prepared by previous polytechnic students during their internship is in compliance with the monograph in the British Pharmacopoeia (BP). There were 3 different samples prepared A, B, and C. My group and I performed the experiments using sample B. For drugs to be deemed suitable for public consumption they must meet certain criteria to ensure that they will not cause more harm than good. Furthermore, we must be certain that the quality of these drugs is consistent. To do this we have to follow and conduct the experiments given in the BP, such as infrared spectrophotometry, limit testing for p-aminophenol in acetaminophen and running the assay for Acetaminophen and only after these 3 tests can we confidently conclude if the sample is up to standard. Introduction Identification by IR IR is a very specific method for identification of active ingredients in pharmaceutical products. An IR spectrum of the active ingredient should be an exact…show more content…
Then it was left to boil under for 1hour. After which round bottom flask was removed from the reflux setup and held first under running room temperature water and then an ice bath until it cooled down enough to comfortably handle it. Next the cooled solution is poured into a 100ml volumetric flask and topped it off to the mark with denoised water. Subsequently, 20ml of this solution was pipetted into a conical flask. To this, 80ml of cold water and 15ml of 2M HCl was added to the conical flask. Afterwards, 0.1ml of ferroin solution (as an indicator) was added. Next, titration was performed. The contents in the conical flask was titrated with 0.1M ammonia cerium (IV) sulphate until a yellow solution was produced. The experiment was then repeated without sample B (only the H2SO4 and water in the proportion 3:7, 6ml acid 14ml
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