Acute Pancreatitis

Background and Objectives: Acute pancreatitis includes a wide spectrum of disease, from mild self limiting symptoms to a fulminant process with multiple organ failure and high mortality. Around 20% of the patients of acute pancreatitis develop acute severe pancreatitis in the form of extensive pancreatic or peripancreatic fat tissue necrosis with associated peripancreatic collections. These patients run a protracted clinical course with high morbidity and mortality. Methods: Clinically, radiologically and by blood investigated, diagnosed 40 patients of acute pancreatitis were prospectively evaluated for the clinical outcome with respect to presence or absence of pancreatic necrosis and severity in terms of CTSI. Results: 24 patients had acute

Patients with pancreatic necrosis with transient end organ dysfunction can be treated conservatively with favorable outcome. The need for intervention should be individualized and based on the clinical condition of patient.

Key Words: acute pancreatitis ,necrotizing pancreatitis , conservative , intervention, treatment.

Introduction

Acute pancreatitis is defined as an acute condition presenting with abdominal pain and is usually associated with raised pancreatic enzymes level in the blood as a result of pancreatic inflammation.[1] Acute pancreatitis may be categorized as mild or severe. Mild acute pancreatitis is characterized by interstitial edema of the gland and minimal organ dysfunction. 80% of patients will have mild attack of pancreatitis, having mortality around 1%.[1] Severe acute pancreatitis is characterized by poancreatic necrosis, a severe systemic inflammatory response and often multi organ failure1. In those who have a severe attack of pancreatitis the mortality varies from 20-50%. About one third of deaths occur in the early phase of the attack, from multiple organ failure,