Addenbrooke Case Study Summary

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Thai version of the Addenbrooke’s Cognitive Examination III: a validation study Abstracts Objective: To validate the Thai version of the Addenbrooke’s Cognitive Examination III (ACE-T) Methods: 147 participants (Dementia, n = 54; MCI, n = 50; controls, n = 43) aged 60 or above were assessed by a psychiatrist using ACE-T. Results: The ACE-T had good internal consistency () and inter-rater reliability (). With the cutoff score >>> the sensitivity and specificity were “”” for MCI, >>>> for dementia. The optimal cut-off score for the ACE-T to differentiate MCI from normal controls was 79/80, giving the sensitivity of 0.74, specificity of 0.84. At the optimal cut-off of 73/74, C-ACER had excellent sensitivity (0.93), specificity (0.95) to distinguish dementia from non-dementia. Conclusion: Thai version of ACE has a high …show more content…

It may not suit for busy general practice clinics or screening in the large number population. ACE measure a broad range of cognitive functions and comprising questions of variable difficulty. This could serve in specialist clinic/center, such as memory clinic or psychiatric clinic. Limitations Our study had some limitations. The majority of our dementia patients received diagnosis of AD, therefore, this limits the generalizability with other type of dementia, for example, frontotemporal dementia and Lewy body dementia. Prior studies demonstrated that ACE could be applied as a differentiating tool between frontotemporal dementia and Alzheimer’s disease; therefore, further studies should be investigated in this issues. The participants in this study are native Thai speaker, and had at least four years of education; consequently, this optimal cutoff point may not be apply to people who use Thai dialect as a first language or had less than four years of education. Test-retest reliability was not evaluated in this

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