. DRUG PROFILE 2.1 IBUPROFEN Ibuprofen chemically known as 2-[4-(2-methyl propyl) propanoic acid. It is a propanoic acid derivative classified under non steroidal anti inflammatory agent (NSAID) with analagesic and antipyretic properties.The empirical formula of ibuprofen is C13H18O2 its molecular weight is 206.29. It is indicated for relief of the signs and symptoms of rheumatoid arthritis and osteo arthritis for relief of mild to moderate pain and also indicated for the treatment of dysmenorrheal. MECHANISM OF ACTION The exact mechanism of action of ibuprofen is unknown.
Rats were fed on high fat diet and received (12 mg/kg) of orlistat daily dissolved in saline (1ml/kg) by intraperitoneal injection (Calderon et al., 2011) for six weeks. Group 4 (G4): represented the group that was treated with amphetamine. The animals received high fat diet and amphetamine in a dose of (1.5 mg/kg) daily dissolved in saline (1ml/kg) by intraperitoneal injection (Geigera et al., 2009) for six
purified through preparative LC as described above and finally characterized as phloretin and phloridzin (Fig. 1). Compound 1 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one or phlorizin was obtained as amorphous powder, mp 2620C. The UV/Visible spectrum of the compound showed λmax at 225 and 285 nm. ESI–MS m/z 297 [M+Na]+ in positive ion mode and 273 [M-H] in negative ion mode for molecular formula C15H14O5; 274.
The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product. Our reaction yielded 3.696% of phenacetin product.
Preservative free dexmedetomidine is available in 1ml and 2 ml ampoule as Dexmedetomidine Hydrochloride for intravenous use (Alphadex, Fusion health care 100 μg/ml). It can also be used for intrathecal and epidural anaesthesia. MECHANISM OF ACTION OF DEXMEDETOMIDINE Dexmedetomidine is the dextro enantiomer of medetomidine, the methylated derivative of etomidine, its specificity for the alpha-2 receptor is 8times that of clonidine, with an alpha-2/alpha-1 binding affinity ratio of 1620:1 & its effects are dose dependently reversed by
Like OPC-67683, Nitroimidazo-oxazine is a nitroimidazole that has demonstrated bactericidal and sterilizing activity against drug-resistant and non drug-resistant TB. Nitroimidazo-oxazine has also shown activity against both active and latent TB. In a 2002 agreement with the former biotechnology company Chiron, The TB Alliance is carrying out phase II clinical testing on Nitroimidazo-oxazine (Diacon et al. ). Nitroimidazo oxaine is also active against latent TB bacteria .In a latent state, bacteria are anaerobic and else replicating very slowly and non replicating.
The peak at 1816 cm−1could is assigned to carbonyl stretching vibrations of carboxylic acids. The band found at 1679 cm−1could be assigned to characteristic asymmetrical stretch of carboxylate group. The symmetrical stretch of carboxylate group can be attributed to the bands present at 1491 and 1354 cm−1. The peaks at 1105 and 789 cm−1were due to the C–O stretching vibrations of polyols, ether and alcoholic
3. Results and discussion 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) is an activated aryl halide that has been used as a chromogenic and fluorogenic reagent for the determination of many drugs with primary and secondary amino groups [22-24]. The reaction of NBD-Cl with LBT has not been investigated yet. LBT contain secondary amino group which can react with NBD-Cl in alkaline medium to form a yellowish green colored product. This derivative exhibited maximum fluorescence intensity at 540 nm after excitation at 476 nm (Figure 2), the maximum absorbance of the reaction product was measured at 480 nm (Figure 3).
Amoxicillin is a penicillin antibiotic that fights bacterial infections. Infections treated by amoxicillin are tonsillitis, bronchitis, pneumonia, gonorrhea, and ear, nose, throat, skin and urinary tract infections. Amoxicillin is a combination with another antibiotic called clarithromycin also used to treat stomach ulcers. Side effects of amoxicillin are yeast infections and diarrhea. Augmentin was the original name for Amoxicillin given by the inventor who was a British scientist at Beecham Research Laboratories in 1972.
This chemical material has a molecular formula of C10H14N2 and its chemical name is 3-[(2S)-1- methylpyrrolidin-2-yl] pyridine. This compound had different chemical and medical effects such as increased sobriety, memory, and activity, but it results in heartbeat, blood pressure and decreased appetite in larger sizes. This action causes interesting medicinal properties which increase rate of such characters by adding nano properties of this structure [7-9]. Extensive HF and DFT calculations on fullerene isomers of C12 and their derivatives have been performed. Relative stabilities of possible isomers of fullerene and the reaction reactivity of the most stable fullerene toward the addition of nicotine have been explored.
The yield of 3-nitrochalcone was 0.786 grams after filtration (percent yield of 62.04%). Multiple peaks were observed in the IR spectrum of 3-nitrochalcone at 1348.14 (N-O bond); 1593.33 (benzene ring); 1658.86 (unsaturated ketone). The carbon-carbon bonds are widely used in the drug industry to manufacture drugs and aldor condensation is used. Figure 1: Synthesis of 3-Nitrochalcone from 3-Nitrobenzaldehyde Source: cnx.org Figure 2: Mechanism Involved in the Synthesis of 3-Nitrochalcone Source: cnx.org