Advantages And Disadvantages Of Paracetamol

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All manufacture of paracetamol follows PNCB process route. Manufacturers of paracetamol in India use
PNCB route and iron / hydrogen reduction to obtain Para amino phenol (PAP), an intermediate for paracetamol. Chlorobenzene with hydrolysis is carried out by the reaction of 9% caustic soda solution with pnitrochlorobenzene. The reaction mass is filtered and with appropriate process control and proper design of the reactor, the yields are optimized, leading into lower requirement of inputs and production of lower quantities of effluent. The sodium salt of p-nitrophenol is treated with concentrated sulphuric acid at 35-45°C. p-Nitrophenol is filtered. With proper filtration and water wash, alkaline liquor trapped into sodium salt of p-nitrophenol is minimized and consumption of sulphuric acid for neutralization is reduced. The dissolved salts content in the acidic effluent is decreased. p-Nitrophenol is reduced with iron at 90-100°C temperature in wooden vat. The temperature increases via direct steam injection. On finishing of reduction, water is added to reaction mass, iron sludge is eliminated by filtration and the filtrate is left to be cooled to 15°C p-Aminophenol is filtered and the filtrate is collected. This filtrate containing p-aminophenol is re-used in the reduction step 4-5 times before being eliminated as wastewater. The design of the reduction vessel along with suitable stirring speed causes the improvement of the product. The iron sludge makes iron oxide for red

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