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Advantages And Disadvantages Of Proteomics

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Introduction
The human body contains a complete set of gene known as a genome while a complete set of protein produced by the genome is known as proteome. Nowadays, with many genome sequencing projects had come to completion such as the human genome project which was completed in the year 2002, researchers had realize that the next challenge is to ascribe function to the discovered proteins in the genome sequencing phase.
Numerous advancements over the past 40 years in protein separation, mass spectrometry, genome sequencing and annotation, and protein search algorithms have led to emerging of the proteomics field (Samaj & Thelen, 2007). According to Kellner (2000), proteomics is the study of proteome and the terms “proteomics” and “proteome” …show more content…

According to Manjasetty (2012), structural proteomics is a protein structure analysis done in a large scale or the process of the high-throughput characterization of biological macromolecules in the form of three-dimensional structures. It is very useful for scientists to predict the biological activities and physiological roles of certain proteins by applying bioinformatics and proteomics-driven approaches. Another advantage to structural proteomics is that researches are able to discover the function of genes that are newly discovered. The long-standing technique: X-ray crystallography and NMR spectroscopy are useful to predict interaction between proteins and are among the main technique in discovering protein structure (Alberts, Johnson & Lewis, …show more content…

Expression proteomics is a large scale analysis of protein expression and it can help to identify main protein that are found in a particular sample and proteins that are expressed differently in related sample; for example damaged vs healthy tissue. Any protein found in a damaged tissue or sample may represent useful drug target or diagnostic marker. Samples can be labelled at the protein or peptide level as in 2D-DIGE and 18O labelling. In this analysis it can be said that proteins with similar expression profiles may also be functionally

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