Advantages Of Cellulose-Based Materials

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2.6 OXIDIZED CELLULOSE: Cellulose-based materials are available as oxidized regenerated cellulose obtained from wood pulp cellulose and oxidized cellulose obtained from cotton fiber. They are completely biodegradable, biocompatible, absorb up to 7 times their own weight. They are available in various forms like single or multiple sheets, mesh, gauze, sponges, and woven strips. Fig 8: Cellulose structure [1] Cellulose acts as a physical matrix to support clot formation. They do not contain any intrinsic coagulation components; but stimulate clot formation and provide a constructive three-dimensional structure for clot organization. In order to function, therefore, a functional coagulation system must be present. [3, 6, 15, 38, 43, 46, 48, 19, 24, 29] Cellulose decreases the pH of its surroundings and results in red cell lysis. This can be seen as brown discoloration of the agent after contact with blood. Leading advantage of the lowered pH is that antimicrobial effect can be perceived against a variety of pathogenic organisms. Moreover, the low pH acts as a caustic agent bringing about hemostasis by creating an artificial clot. But, disadvantage is that the low pH causes inactivation of other biologically active agents like thrombin, which limits its…show more content…
It acts as a sieve with hydrophilic effect concentrating the solid constituents of blood, improving barrier formation, and assisting with normal activity of PLTs and blood clotting proteins. This result in swelling up to 500 percent and thus avoided in closed space and it should not be used in neurologic, urologic, or ophthalmic surgery. The product is delivered as a powder in a bellows applicator that is ready to use. It is effective in treating capillary, venous, and arteriolar bleeding. It is usually absorbed in 24 to 48 hours. A unique concern is that these spheres are composed of sugar and hence more than 50g should not be used in diabetic patients. [24, 38,

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