4.1 Amaranth powder.
Aim
To prepare 25g of amaranth powder.
Theory
Amaranth – Dark red/purple powder, slightly odourless used as dye in medicines and colouring agent for foodstuff.1
Zinc oxide – odorless white to yellowish white powder, bitter tasting, insoluble in cold water, hot water soluble in dilute acetic acid solution. Keep in closed/locked container, keep away from acids. Hazardous in case of inhalation. 2
Starch – White powdered solid, slight odor, combustible at high temperatures. Keep container tightly closed, keep in a cool well ventilated area below 24degrees celcius.3
Talc – White/ grayish white powder, insoluble in cold water, hot water. Keep in tightly closed container. Keep in cool well ventilated area.4
Calculations
(0.16%/100)*
…show more content…
TEL 01137830-A
L.A GRAAF, B Pharm. After hours 0374904
4.3 Paediatric powder.
Aim
To prepare a paediatric paracetamol each pack containing 0.25g powder.
Theory
Paracetamol- A white powder, odourless, should be stored in a well ventilated place.10
Codeine phosphate – A white powdered solid, odourless, partially soluble in menthanol, insoluble in diethyl ether, soluble in cold water. Should be stored in an airtight container.11
Lactose ad – A white slightly sweet odourless powder used mostly to bulk powder up, should be stored in an airtight container.12
Formula Original Working
Rx Paracetamol 50mg 1.0g
Codeine phosphate 5mg 0.1g
Lactose ad 250mg 5.0g
Method
1. Weighed codein phosphate and poured 0.1g in a mortar.
2. Weighed 1g paracetamol and added to the mortar, grinded with pestle until fine.
3. 5g-(1g+0.1g) = 3.9g of lactose was added and mixed in the mortar.
4. 3 doses of 0.25g packs were made and folded accordingly.
Results
A white powder, fine, odourless, free flowing, bitter tasting.
…show more content…
TEL 01137830-A
L.A GRAAF, B Pharm. After hours 0374904
4.4 Chalk powder
Aim
To prepare 50g of chalk powder.
Theory
Activated charcoal- A black solid/solid powder, odourless, black insoluble in cold water, hot water. Incompatible with air, should be stored in a closed container.13
Calcium carbonate – An odourless tasteless powder or crystal used as a calcium supplement, insoluble in water.14
Light kaolin - A white powder, insoluble in cold water, hot water, methanol, di-ethyl ether, n-octanol. Store below 23 degrees Celsius, keep container closed tightly.9
Heavy magnesium carbonate – A white odourless powder, should be stored in an airtight container.15
Sodium bicarbonate A white crystalline powder or lumps, slightly alkaline mostly used as a pH buffering agent, should be stored in a closed container.16
Formula
Rx original working Activated charcoal 5g 0.25g
Calcium carbonate 370g 18.5g
Light kaolin 125g 6.25g
Heavy magnesium carbonate 125g 6.25g
Sodium bicarbonate 375g
Prelab week 1 Calculations Preparation of 1.5μmol/L mixed low-level standard dilution 150μmol/L × V1=1.5μmol/L × 10ml V1=(1.5μmol/L×10ml)/(150μmol/L)=0.1ml Conversion of milliliters to microliters (0.1ml×1000)μL= 100μL Preparation of 3μmol/L mixed low-level standard dilution 150μmol/L × V1=3μmol/L × 10ml V1=(3μmol/L×10ml)/(150μmol/L)=0.2ml Conversion of milliliters to microliters (0.2ml×1000)μL= 200μL Preparation of 3μmol/L mixed low-level standard dilution 150μmol/L × V1=7.5μmol/L × 10ml V1=(7.5μmol/L×10ml)/(150μmol/L)=0.5ml Conversion of milliliters to microliters (0.5ml×1000)μL= 500μL Preparation of the blank samples The volumetric flask will be filled to the mark with 150μmole/L of stock solution to act as blank (reference). Additional two blanks will
Is dark blue color color going to grayish black . 2nd in commercial value is pyrolusite. This mineral is thought to have been deposited by ground water carrying manganese.
5-aminotetrazole monohydrate: In a 250 ml round-bottom flask equipped with a condenser for refluxing (90 °C) and a magnetic stirring bar, 5.00 g (5.95 mmol) dicyandiamide (three times crystallized), 7.47 g (11.9 mmol) sodium azide and 11.00 g (17.8 mmol) boric acid and 100 ml of water is added and allowed to reflux for 24 hours, after the completion of the reaction, until the solution pH to about 2 to 3 as hydrochloric acid 37% is added (about 12 ml) Then the reaction mixture was cooled in a refrigerator for 18 hours and the white crystals formed. The mixture was filtered and washed three times with 10 ml of water and and dried in 60 °C for 5 hours and finally 45.8 g of product by it will be obtained. 5-Aminotetrazol monohydrate:
The iodine turned a dark blue almost purple color when it was combined with starch. I tested iodine on a piece of cut potato and once in contact it turned a dark blue-purple color therefore stating starch was present. I also placed starch on a piece of paper, when it cam in contact the iodine just ran but did not change color. Lastly I tested the starch on a piece of white bread. Immediately it absorbed the iodine but did not change color therefore there was not starch.
o Are the individual ingredients all present at active dose levels? o Is the dose spacing appropriate for each ingredient? o Is the recommended dose appropriate? (If not, discuss what dose / how much of the product would you recommend OR why it is not possible to recommend an appropriate dose.) How to present and submit your assignment •
My group and I determined that each of the powders state was solid, all of them were a white colour, and they were all opaque. 3. What other physical properties could have helped to identify te mysery powder? Why were these properties not tested in this activity?
Wt. Mass Density Appearance 2-methycyclohexanol 0.75 mL 114.19 g/mol 0.93 g/mL Clear colorless liquid 85% Phosphoric acid 1.00 mL Clear
The overall aim of our experiment was accomplished due to the fact that the compound produced was tested to be pure paracetamol. Its purity was tested by TLC, melting point range and NMR analysis. For the Melting Point Range Determination, samples of our re-crystallised p-aminophenol and paracetamol were placed into capillaries and into the melting point apparatus where data was recorded during the melt. Then, for the Thin Layer Chromatography, a TLC plate was prepared with four small dots loaded with p-aminophenol, our recrystallised p-aminophenol, our resultant paracetamol and commercial Panadol® respectively. When TLC was completed, it was transferred to a UV lamp box for analysis and data collection.
ONPG produces the yellow color. The time was recorded when each tube turned yellow and incubated for 5 minutes in the water bath. 1ml of sodium carbonate (Na2CO3) is added to each to tube in order to develop the color as well as stop the reaction between ONPG and beta-galactosidase which will in turn stop the enzymes activity allowing us to measure the absorbance with no rush. The tube that turns yellow first is the one that has the highest levels of beta-galactosidase. It was hypothesized that the tube with the greatest amount of beta-galactosidase is produced in the tube that had the lactose mixture in the shaker for the longest time.
In this lab, we tested 8 known ingredients to find what ingredients was in our unknown A and unknown B medications. We first tested the water solubility of our knowns and unknowns. We found that of the knowns, cornstarch and acetaminophen were the only ones not water soluble. The unknowns were also not water soluble. Th next test was the pH test.
Chemical compounds that are available to determine are CaCO3, CaCl2, Ca(NO3)2, mgCl2, MgSO4, KCl, HCl, HC2H3O2, KNO3, K2SO4, NaC2H3O2, Na2CO3, NaCl, Na2SO4, HNO3, H2SO4, HNO3, H2SO4, NH4Cl, (NH4)2SO4, K2CO3, 0.1 M AgNO3, 0.2 M BaCl, Mg(s), NaOH, and KOH. To start this experiment, start with the flame test by gathering a Bunsen burner and a Nichrome wire. Connect the Bunsen burner with a rubber tube to a laboratory gas. To prepare solutions for the flame test, weigh out 0.205 gram of Unknown Compound using an analytical balance and mixed it into a 140 mL beaker filled with 20 mL ionized water. Ensure that solid is completely dissolved using a stirring rod.
Based on our initial observations(appearance) of solid #4 and the fact that they are not soluble in water and will sink, my partner and I have concluded that solid #4 are small pebbles. Solid #2 are small pieces of tin foil. We believe this because solid #2 isn’t soluble in water and doesn’t float just like tin foil. We also think this because of our initial observations(appearance). Nika and I believe that solid #6 is dried up purple food coloring because once you put the solid in water it dissolves and the water becomes purple(just like the color of our sludge).
[…] This powder being chewed or swallowed, or washed down, by a small Cup of Water, doth, in a short Time, quite take away the Memory and Understanding; […], being unable to speak a Word of Sense; yet he is very merry, and laughs, and sings, and speaks Words without any Coherence, not knowing what he saith or doth; yet his not giddy, or drunk, but walks and dances, and sheweth many odd Tricks; after a little Time he falls asleep, and sleepeth very soundly and quietly; and when he wakes, he finds himself mightily refresh’d, and exceeding hungry. […] It may therefore, if it can be produced, possibly prove as considerable a Medicine in Drugs, […]; and may possibly be of considerable use for Lunaticks, or for other Distempers of the Head and
C12H22O11 (lactose) + H2O > 4CH3CHOHCOOH (lactic acid) is the equation for lactose to lactic acid.
Analysis Conclusion Based of the data collected from the experiments, cornstarch was identified as the unknown powder in the black bag. Cornstarch shares similar chemical properties compared to the unknown powder. They both have a pH of 7, contain starch, but not carbonate, and react with the flame to create a temporary bright orange. Even so, powdered sugar also has the same chemical properties. However, when the powders were viewed in the Scanning Electron Microscope, the powdered sugar grains looked nothing like that of the unknown sample.