Huntington disease, is a neurological disorder of the brain
Dr. George Huntington a young American who has complete is doctoral degree, has revealed this disease in 1872. Therefore, the disease was named after him. Huntington’s disease is one of the more tragic movement disorders, and if a parent has this disease, the child is 50% more liable to get the disease. . Doctor George Huntington was not the first to describe the disorder, however, he was the first to write an accurate article, and description of the disease. At the time it calls chorea, which, management is the Greek word for dance. The term chorea describes how people are struggling with the disorder. Constant movements appear to be uncontrollable. Later on the symptoms of
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According to Pub Med (2011):
The deficiency cause a part of DNA, called a CAG duplicate, then it is supposed to. Normally Huntington’s disease is a hereditary disease that causes deterioration of the nerve cells within the brain. It is in Neurological disorders, such as inability to control body movements, uncontrollable tremor, loss of sensation, memory disorders and involuntary speech tic are complicated and have a profound effect on a patient’s quality of life regrettably, at this time there is no cure for the disease.
The symptom of this disease can diverge between individual and affect a member of the family (According to journal Neurodegeration) the deterioration of the brain, also lead to dementia, Altheimers, and Parkinson.
, this section of DNA is repeated 10 to 28 times. However, as someone with Huntington's disease will repeated 36 to 120
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Fetal brain tissue transplantation
Has also helped in Parkinson's disease patients. While there has been a few of these transplantations perform for HD patients, it is still too early to evaluate its success. Of chorea. Since the Huntington protein causes a gain of function instead of a loss of function, normal gene therapy techniques normally do not work. Instead, the Protein should be disinterested or it will grow of significant effects must be introverted.Currently, move toward makes additional sense, since we previously know how the
Huntington protein interactions with other proteins and we can, through this
Knowledge, find modulators to treat the disease. In conclusion, Huntington's disease is a degenerative disease of the
Mind and body. It ultimately causes death. While current treatments can only
Helping the symptoms, it is hoped that further research and new techniques will
Bring about an effective
Duchenne Muscular Dystrophy is a disorder that is both mentally and physically challenging. Duchenne Syndrome is caused by the mutation of a gene on the X-chromosome. A muscle protein, dystrophin, is affected by this mutation. The damaged gene cannot make enough dystrophin to work right, so it will result in DMD. Dystrophin is a protein that is associated with muscles in the heart, bones, and some in the nerve
Not only does it affect the person who has it but also their family. Mrs. Levy, the individual who has Parkinson’s struggled to live with it because she faced many obstacles. It was the support of her family and doctors who helped her overcome the difficulty that Parkinson’s brought to her. Scientists and researchers have evolved in the knowledge of Parkinson's disease over the past several years. There is still more research going on today in finding a cure for the disorder along with finding other ways to help produce dopamine in the brain.
The novel Awakening by Oliver Sacks opens with a story about a young women, Frances D. who at the age of fifteen begins to experience “severe attacks of encephalitis lethargica”. In 1964 at the age of sixty Miss D. was finally labeled as having Parkinsonian. Miss D. experienced many symptoms of the Parkinson’s Disease earlier in her life before she was classified as having Parkinsonian some of these symptoms were, freezing during movement or speech, oculogyric crises which would last as long as fifteen hours on end. The passage goes on Oliver Sacks continues to talk about Miss D.’s struggles and complications with the disease, Miss D.’s biggest struggle that I had analyzed was her not being able to control her own actions, “I am a quiet person,’
Michael J. Fox is an actor and a writer that was diagnosed at the age of 29 with Parkinson’s disease. When he found out he said, “It was the last thing I expected.” He speaks about his disease regularly and started the Michael J. Fox Foundation, whose goal it is to eliminate Parkinson’s disease. “It is the largest nonprofit funder of Parkinson’s Disease drug development in the world.” And because of this foundation, he was able to control his symptoms and side affects enough to go back to acting by finding a drug cocktail (The Biography of Michael J. Fox).
This disease is induced by the loss of dopamine production from dopaminergic (DA) neurons. These neurons have long microtubules-enriched axons. Parkin, a microtubules-associated protein, binds strongly to the microtubules, and acts as a protein-ubiquitin E3 ligase that ubiquitinate misfolded proteins to be relocated to the cytosol, and to stabilize the microtubules. The mutation of gene that responsible of the production of parkin can cause the dissociation of parkin from microtubules, which leads to the depolymerization of microtubules. The free tubulin dimers from depolymerization will be ubiquitinated and degraded by the parkin protein (Figure 9).
This disease is called Huntington’s disease (HD). [1,2,3] While some differences between Parkinson’s disease and Huntington’s are noticeable, the similarities are striking. The similarities in causes, symptoms and treatment of both PD and HD are the most apparent. At first, PD is caused by some genetic factors, and HD is, too. [4,5] Like PD, HD has equal movement symptoms that are characterized by an abnormal way of movement such as walking in *an unbalanced way.[6,7] Also, both PD and HD affect the patient’s personality and memorizing ability, which usually leads to cause depression and forgetfulness.
Parkinson’s affects the central nervous system eventually leads to triggering in the hand. Alzheimer 's is a disease that affects the memory and important mental functions. Dementia is when a person think a lot which interferes with their daily functions. Huntington’s an inherited condition when nerve cells starts to lose the ability over a period of time. Athletes who come in contact with sports are more like like to get it because in a game there is usually hitting each other or even getting injured dramatically.
Dementia is a brain disorder that affects communication. Dementia is diagnosed by symptoms, while Alzheimer’s is diagnosed by brain scans. A person with Dementia can do a task, but they just forget they did it. A person with Alzheimer’s forgets how to do the task altogether. Huntington’s and Parkinson’s disease are also both similar to each other.
" Studies of Huntington’s with brain scans show that some people already have the disease, years before any symptoms appear. To provide accurate and clear images of specific biochemical
Over 5.5 million Americans of all ages had Alzheimer's disease in 2016 and it is the sixth leading cause of death today. This appalling disease is genetic, which means that it can go through generations of a family. With many diseases having a cure, medical scientist can’t seem to find a cure for Alzheimer’s. People may argue that we are doing enough for the Alzheimer’s disease because we are persisting to search for a cure every day. However, with so many side effects on the patients and furthermore the family of these patients, we legitimately aren’t doing enough for this daunting disease.
However there are treatments that can slow down the process of the disease. Surgery is often suggested because of the tumours that can become cancerous and tumours that can cause body disfigurement. The symptoms that are ongoing throughout the disease like severe headaches they can be cured with medication. Children that inherit the disease at birth have a higher chance of having learning difficulties and neurological tests have to be taken before the child enters school and neurological counselling is a common solution to help the child be able to
Parkinson’s is one that can affect the physical and mental ability of a child growing
has developed an investigational drug called drisapersen for the treatment of DMD. This drug aims to treat 13% of the patients who are responsive to exon 51 skipping treatment. This represents the largest subpopulation of DMD patients, including patients with deletions of exon 50, exon 52, exons 45-50, exons 48-50, and exons 49-50. DMD is caused by the mutations in the dystrophin protein gene. Mutations are, mostly, deletions of one or more exons that interrupt the open reading frame of the transcript and eventually stop the synthesis of the dystrophin protein.
Also, gene editing can get rid of conditions in unborn children. A breakthrough gene editing tool, CRISPR, is allowing researchers to be more and more accurate when modifying genes. This new technology allows researchers to begin to edit embryos and edit the genes that will lead to illness and disease. Preexisting conditions such as hemophilia, thalassemia, Tay-Sachs disease, spinal muscular atrophy, and Duchenne’s muscular dystrophy can all be treated by gene therapy. Tay-Sachs disease and spinal muscular atrophy both affect the brain and spinal nerves and neurons.
It is a de-generative disease of the brain that leads to a condition called dementia” (in-text citation for a journal).