Angiogenesis Research Paper

Abstract
Angiogenesis is a physiological process that causes the growth of new blood vessels from pre-existing vessels. This process is regulated both by activating molecules and inhibitors of angiogenesis and also played a key role in physiological processes such as organ growth and development, wound healing and reproduction and in the pathological process of tissue destruction including tumor growth, metastasis, arthritis, etc. Generally, process of angiogenesis is influenced by several factors that led to a series of cellular events such as migration, growth and proliferation of endothelial cells and eventually result in the formation of new blood vessels. For this reason, angiogenesis inhibition in the treatment of many cancers, degeneration of an eye patch, and also in the treatment of diseases resulting from proliferation of blood vessels is used. The process of angiogenesis is influenced by several factors that led to a series of cellular events such as migration, growth and proliferation of endothelial cells and ultimately leads to the formation of new blood vessels. In recent studies, inhibition of

- Angiopoietin-2(Ang-2) ,Ang ( angiogenin) , epidermal-derived factor(EGF) , placental growth factor(PGF) , vascular endothelial-derived factor(VEGF) ,VEGFR and NRP-1, TGFα or β (growth-modifying factor) ,basic or acidic fibroblast growth factor (aFGFand bFGF) , platelet-derived growth factor (PDGFR and PDGF) , a clone stimulating factor CSF(G-CSF),Endothelin-1,tumor necrosis factor(TNFα) ,Integrin, Eph Receptors and Ephrin Ligands, Cyclooxygenase-2 and nitric oxide synthase(Cox-2-and eNOS) , bacterial lipopolysaccharide (LPS) , transmitted by hypoxia inducible factor (HIF-1) , hepatocyte growth factor and scatter factor (HGF / SF) , Erythropoietin (EPO) , Cathepsin B ,cathepsin S, Thrombopoietin (TPO) ,monocyte chemotaxis protein(MCP-1) , Histamine, plasminogen activators , Plasminogen activator inhibitor ,AC133 Id1/Id3,VE-cadherin and CD31