Angiogenesis And Photosynthesis

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Potential of Dillenia philippinensis Rolfe Leaf Ethanolic Extract to Arrest Angiogenesis in Chorioallantoic Membrane of Duck Embryos*
Julius Czar F. Baguio1

Abstract – Angiogenesis involves the formation of new blood vessels. However, an imbalance in angiogenesis may lead to cancer growth and development. Bioactive compounds present in plants is being scrutinized as a source of anti-cancer drug. In this study, the potential of the Philippine native plant, Dillenia philippinensis to arrest angiogenesis was examined using chorioallantoic membrane (CAM) assay. Fresh leaves of D. philippinensis were dried and subjected to extraction using 95% (1:5 v/v) ethanol. The extract was partitioned into 25%, 50%, 75% and 100% (solvent) as the experimental group. 90% ethanol and Retinoic acid were used as negative and positive control respectively. The results revealed that angiogenesis was induced in the negative control while inhibition in the growth of blood vessels was observed in the treatments …show more content…

philippinensis constitutes phytochemical compounds such as triterpenoids betulinic acid and 3-oxoolean-12-en-30-oic acid that has a potential angiosuppressive property (Ragasa et al., 2009). Betulinic acid is a pentacyclic triterpene that is derived from the widely distributed natural anti-cancer compound botulin. According to Dehelean et. al. (2011), betulinic acid does possess an anti-angiogenic activity but it would still depend on the amount of dose and also the nanoemulsion formulation maintained the effect. Moreover, betulinic acid inhibits in vitro enzymatic activity of aminopeptidase, which is known to play an important role in angiogenesis (Kwon et., al, 2002).
IV. CONCLUSION This study showed that as the concentration of extract increases, the number of blood vessels decreases. Thus, it can be concluded that the leaf ethanolic extract of Dillenia philippinensis possesses bioactive compounds that have a great potential source of anti-cancer drug.
V.

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