Angiotensin Aldosterone Lab Report
To determine if the Renin-Angiotensin-Aldosterone system is the ultimate controlling system in terms of why and how it functions.
Definition of the topic:
The Renin-Angiotensin-Aldosterone system is being evaluated to determine if it is the ultimate controlling system. Composed of various components such as the renal, liver, adrenal gland and cardiac system. This system interlinks all its components to carry out its function. To determine the functions of the three hormones; renin, angiotensin and how they perform the role of regulating blood volume and sodium balance
Body
Function:
The Renin-Angiotensin- Aldosterone system functions in the regulation of sodium for optimal balance. It also regulates the volume of fluid such as blood and blood
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The α2- globulin, Angiotensinogen is secreted from the liver. Renin in turn hydrolyzes the plasma globulin present in Angiotensinogen which acts as a precursor protein to form the precursor hormone Angiotensin I. Angiotensin I in its inactive state is converted to Angiotensin II which is active, this is done by angiotensin converting enzyme (ACE) secreted from the lungs (Ghany, 2011).. ACE also cleaves bradykinin to inactivate it producing fragments of the inflammatory mediator. Angiotensin II is present as an octapeptide acts as a vasoconstrictor hormone that results in the increase of blood pressure, renal perfusion and filtration rate by the glomerulus. Angiotensin II acts as a mediator for the Renin-Angiotensin-Aldosterone system, it does this by activating Angiotensin type 1 (AT1) receptor and Angiotensin type 2 (AT2) receptor. The AT1 receptors stimulate the production of aldosterone from the adrenal zona glomerulus. The receptors are found in vasculature,
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