Antagonistic Effects Of Methadone

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Methadone exists as two enantiomeric forms, R and S (Eap et al., 2002). The most commonly used form of methadone in maintenance treatment is the racemic mixture (RS- methadone) (Groman et al., 1997). It is the R-isoform that gives most of the opioid effects (Eap et al., 2002). Methadone exerts its analgesic and narcotic effects through the µ-OR subtype, and has antagonistic effect at the NMDA receptor (Trescot et al., 2008). The antagonistic effect at the NMDA receptor is believed to be advantageous in preventing induction of tolerance (Callahan et al., 2004). The half-life of methadone is variable between individuals and ranges between 24 and 48 hours (Curran et al., 2000). Enzymes contributing in metabolism also vary, but it is primarily

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