INTRODUCTION
Asthma is a condition and chronic inflammatory disorder of airways that directs to airway obstruction. It is distinguished by airway hypersensitivity to diverse types of stimuli, result to a sudden yet transient constriction of the muscles in the walls of the bronchioles and airways, leading patients to experience wheezing, chest tightness, shortness of breath and cough. Asthmatic attacks can be triggered by extrinsic factors such as allergens, smoke, pollution, mold spores and food, or intrinsic factors such as airway infections, emotional stress, exercise, acid reflux and fatigue. Asthma is one of the common diseases in the Philippines caused by the country’s poor environment. Asthmatic attacks can often be controlled by
…show more content…
The main focuses of the study are the primary and secondary effect of the selected antihistamine/s on to the subject. The researchers shall use a therapeutic drug as a control. Bromelain will be the primary antihistamine following with quercetin as its adherent. Compatibility between bromelain and quercetin shall be tested in the process.
Each subject will undergo checking, aimed at their initial WBC account. They will be observed for the indications of asthma. Subjects will each apply different sets of antihistamine. First is the application therapeutic drug on the first subject that will serve as a control. The second subject will apply bromelain, and the third will have both bromelain and quercetin. Second WBC count will be performed after. Researchers will then, compared the initial and the latter WBC account and the signs and symptoms confirmed by the rats. This will then, give the in vitro studies.
After comparison of results among the subjects, two that applied bromelain and both bromelain and quercetin shall go through histopathology wherein researchers will observe the effects applied by the antihistamines in
…show more content…
There is insignificant reaction with the bromelainextract from the pineapple,Anasascomosus,and the laboratory rat with induced asthma.
2. Bromelain cannot enchance the antihistamine property of quercetin extracted from mung beans sprout.
3. There might be an incompatibility between bromelain and quercetin that would have an effect towards the subject.
SIGNIFICANCE OF THE STUDY Asthma is one of the most common illnesses of the Filipinos. One of the components of anti-asthma drug is the anti-histamine. Using the bromelain as an anti-histamine drug came from natural resources like pineapple juice and pineapple stem. The study shall contribute to the understanding of the said chronic disease. Other researchers can use this study as a supplementation for future research about asthma. Simple information about mung beans and pineapple plants in this study can further manifest community’s practicality for health by using its extract as natural remedies. In this study, the research aims to find if bromelain itself can reduce the asthma attack faster than the generated medicine in the laboratory. With this, we can introduced to the people to use a natural medicine than the generated medicine in the
“You have the mind but you have not the body, and without the help of the body, the mind cannot go as far as it should. You must make your body. It is hard drudgery to make one’s body, but I know you will do it” Teddy got told. He liked to wrestle and box for exercise. Theodore’s father was a great asset to him, and he helped Teddy through complicated situations, asthma being one of them.
How does this improve Mike’s asthma? - Albuterol is used to relax the muscles that are in the bronchioles to relieve breathing. It relaxes smooth muscle by decreasing the calcium ions. Calcium ions are necessary to produce muscle contraction. It improves Mike’s asthma because it is relaxing his smooth muscle, which allows for a clear pathway for airflow to help him breath
year- old that loves to follow behind his brother. She reported that he is busy and loves playing with others. Ms. Leonard reported that Samuel currently has asthma and takes two medications. Samuel currently takes Albuterol and Bromfed DM. She reported no asthma attacks.
The last environmental factor that can cause asthma attacks is the weather. Extremely cold air, dry wind, and sudden weather changes can trigger asthma attacks. Eastern NC, including Duplin County, has been
Part 1 Some of the common things that trigger an asthmatic episode are cigarette smoke, exercise, allergens, sudden temperature change, excitement or stress, cold air, and odors. Some factors that could have affected her is going upstairs, going from standing to sitting position, the dust and allergens, the smell of coffee and the teddy bear as well.
They interviewed and did physical exams on study participants who had different experiences with asthma. There were no major differences in household income, sex, smoking status, health insurance coverage, race/ethnicity, and depression
Asthma is diagnosed with a history, physical exam, laboratory findings, and pulmonary function studies. The strongest risk factor for developing asthma is a genetic predisposition to immunoglobulin E-mediated response to common allergens. Damage to bronchial epithelium and airway inflammation contributes to the pathogenesis. T2 helper cells respond to allergens by stimulating B cells to differentiate into immunoglobulin E producing plasma cells. T2 helper cells also stimulate growth factors for mast cells and activate eosinophils.
The effectiveness of using these three drugs on a people with smallpox has not been established since they have not been tested on people that had the disease. In the event of a smallpox outbreak consideration may be given to use these
Meaning if the extract inhibits cilia, the affects for the human functioning airways would become weak due to cilia being the one that helps move the airway surface fluids and mucus. Providing continuous cleansing of the airway surface, which is a vital defense against inhaled particles. Materials and Methods a. experimental design: To begin the experiment we made two groups one called the control group and one called the experimental group with tobacco. For the control group we added a mixture of 20 microliters of tetrahymena, 1% India ink and 1% of glutaraldehyde to a microscope slide to create the control group . In the experimental tobacco group we added the same amount of substances only difference was 50 microliters of tobacco extract was added to the mixture.
Severe asthma attacks can result in total blockage of the bronchi, leading to hypoxia and then death if not re-opened. Atopic asthma can be induced by hypersensitivity to foreign particles such as dust mites. Alternatively, asthma may be non-atopic, caused by an upper respiratory tract
Asthma has a significant impact on society, affecting over 6 million children under the age of 18 in the United States alone. Reasonable ways to control this disease are medications such as inhalers and spirometry to test the strength of your lungs. There is a myriad factor from environmental constraints, physical and the one built by humans is noted as a major factor affecting the development of asthma. Indoor air pollution is the most common form of air pollution, along with first-hand and second-hand smoking. Air pollution is often greater in lower socioeconomic neighborhoods with mold and cockroach infestations and access to medical care.
Emphysema is a chronic respiratory disease that affects millions of people worldwide. The fourth-leading cause of death in the United States, COPD affects about 16 million Americans and kills about 120,000 people per year (Wisniewski, 2003). Emphysema is one of the two types of common lung diseases known collectively as COPD, which is known as chronic obstructive pulmonary disease. Of the two types of COPD, emphysema is the most severe form. Many etiological factors can contribute to this disease such as age and genetics.
How could you have been able to you feel when you first heard you had asthma? I didn 't precisely comprehend what it implied so I couldn 't have cared less excessively. In any case, when I realized what it was and what it implied I was frightened and thought I would not have the
Asthma is a chronic illness that is widespread over the United States with 24 million people affected; and 7 million alone are children (Morris, 2015). With this disease, the airways are constantly inflamed; and when a trigger is inhaled or presented, inflammation increases causing distress in the airways. The airways then constrict and breathing becomes a challenge. Asthma occurs in “attacks” and common symptoms include wheezing, coughing, and dyspnea (Asthma: Overview, 2014).
An organ bath experiment was conducted to investigate the effect of agonist, histamine on guinea pig ileum (GPI) and how the antagonists, mepyramine and SIPBSDrug A affect the GPI’s response (smooth muscle contractions). A GPI simulation was conducted to compare the potencies and nature of antagonists against histamine. The control Rmax and EC50 of histamine without antagonist were 16.49gms and 2.093 x 10-7M respectively. The concentration-response curves were shifted to right parallelly and EC50 increased while Rmax remained constant when mepyramine or SIPBSDrug A was added. Besides, both antagonists showed linear graphs in Schild plot, indicating that they acted as reversible competitive antagonists.