Azithromycin Dihydrate Narrative Report

DEVELOPMENT AND EVALUATION OF AZITHROMYCIN DIHYDRATE FAST DISSOLVING TABLET

Jyotsana Madan1, Pradip Kumar Karar2, Gaurav Agarwal*2

1 SKN College of Pharmacy, Pune (Maharastra) India
2 Faculty of Pharmacy, RPIIT Campus, Karnal (Haryana) India

ABSTRACT
The aim is to formulate fast dissolving tablets of Azithromycin Dihydrate which is intended to disintegrate rapidly into the oral cavity using different super disintegrants. The wet granulation method was used because direct compression method failed to formulate dispersible tablet. The different super disintegrant used were Sodium starch glycolate (SSG), Croscarmellose sodium (CCS) and Crospovidone (CPV). In all the formulations water was used as a binding agent. The finally prepared fast

The Prepared fast dissolving tablets should disintegrate rapidly in oral cavity within 15-60 seconds, without water. The super disintegrant ( Sodium starch glycolate, Croscarmellose sodium & Crospovidone) were used to formulate the tablets. Fast dissolving tablet of Azithromycin dihydrate were prepared by wet granulation method according to the formula given in Table 1.
Initially all the ingredients were passed through 66 mesh separately. Then the granules were prepared by using SSG,CCS & CPV, sodium lauryl sulphate and avicel as intragranular ingredients using water as a binder passing lumps through 8 mesh. Then extragranular ingredients were weighed and mixed in geometrical order with prepared granules and compressed into tablet of 400 mg using 11mm flat punches on single punch tablet compression machine. A batch of 30 tablets were prepared for each of the designed

Preformulation yields basic knowledge necessary to develop suitable formulation for the toxicological use. It gives information needed to define the nature of the drug substance and provide frame work for the drug combination with pharmaceutical excipients in the dosage form. The following preformulation studies were performed.

1. Bulk Density (Db): It is the ratio of total mass of powder to the bulk volume of powder. It was measured by pouring the weight powder (passed through standard sieve # 20) into a measuring cylinder and initial weight was noted. This initial volume is called the bulk volume. From this the bulk density is calculated according to the formula mentioned below. It is expressed in g/ml and is given by
Db = M/ Vb
Where, M is the mass of powder, Vb is the bulk volume of the powder.
2. Tapped Density (Dt): It is the ratio of total mass of the powder to the tapped volume of the powder. Volume was measured by tapping the powder for 750 times and the tapped volume was noted if the difference between these two volumes is less than 2%. If it is more than 2%, tapping is continued for 1250 times and tapped volume was noted. Tapping was continued until the difference between successive volumes is less than 2 % (in a bulk density apparatus). It is expressed in g/ml and is given