Antibiotic Combustion

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2. Aim and Objectives

2.1 Aim The aim of the present study is to select a suitable antibiotic combination for broad spectrum action against gram negative and gram positive organisms in an autoinjector for field use in emergency and to evaluate its effectiveness, tolerability, safety and accessibility.
2.2 Objectives of the study
1. To select a suitable antibiotic combination that should be effective against various gram negative and gram positive bacteria and evaluate quality all control parameters.
2. To study the haematological and biochemical changes in response to stress induced by administration of antibiotic combination by autoinjector in comparison with manual injection in animal model.
3. To evaluate the efficacy of
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military, atropine and 2-PAM-Cl (pralidoxime chloride) are used for first aid ("buddy aid" or "self aid") against nerve agents. An issue item, the Mark I NAAK (Nerve Agent Antidote Kit), provides these drugs in the form of two separate autoinjectors. A newer model, the ATNAA (Antidote Treatment Nerve Agent Auto-Injector), has both drugs in one syringe, allowing for the simplification of administration procedures. In the Gulf War, accidental and unnecessary use of atropine autoinjectors supplied to Israeli civilians proved to be a major medical problem. (Baren et al., 2007) In concert with the Mark I NAAK, diazepam (Valium) autoinjectors, known as CANA, are carried by US service members.The first aid kit developed by Defence Research and Development Organisation (DRDO) contains detection, decontamination and medical protection for chemical warfare agents including auto injectors for rapid administration and faster absorption of drugs. (Vijayaraghavan, et al 2012)The nerve agents like tabun, sarin, soman and Vx act rapidly and hence for medical protection, the antidotes are provided as autoinjectors in the first aid kit.(Vijayaraghavan,

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