Bambara Nut Starch Lab Report

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Impact of thermal and chemical modifications on the compression and release properties of Bambara nut starches in directly compressed tablet formulations Abstract: A variety of chemical and physical modification can be used to modify starch and impart desired properties to the starch. The objective of the present study was to investigate the compaction, mechanical and release properties of thermal and chemically modified starches from Bambara nut in Ibuprofen tablet formulations. The native starch extracted from Bambara nut was modified to obtain the pregelatinised and carboxymethylated forms. Compressional properties were analyzed using density measurements and compression equations of Heckel, Kawakita and Gurnham. The mechanical properties…show more content…
This is of particular relevance during powder mixing, filling of capsules with powders or granules, and filling of dies during tableting operation [8]. The compaction properties of pharmaceutical formulations can be studied experimentally using a variety of techniques, ranging from instrumented production presses to compaction stimulators [9]. A compaction equation relates some measure of the state of consolidation of a powder, such as porosity, volume or relative volume, density or void ratio, with a function of the compaction pressure. The initial purpose of fitting experimental data to an equation is usually to linearise the plots so as to make comparison easier between different sets of data [10]. The relationship between volume and applied pressure during compression is the main approach used in deriving a mathematical representation of the compression process [11]. Basically, during compression of powders, volume reduction occurs as a function occurs as a function of compression force; thus, the widely used method in describing the compaction processes of powders involves measurement of porosity changes as a function of the compression pressure [12]. A single equation cannot be used to characterize the compression behavior of excipients, hence the tablets’ compressional characteristics have been studied using density…show more content…
Bambara groundnut is an underutilised crop predominantly grown in African countries [19,20] and is mainly cultivated in Sub-Saharan Africa's warm tropics [21]. Bambara groundnut is very nutritious, having 65% carbohydrate content and 18% protein [22]. The need for locally sourced raw material for pharmaceutical manufacturing is critical as it lowers manufacturing costs, creates jobs in multiple areas like planting, harvesting, and crop storage [23]. A previous study [24] investigated the heat stability and pasting properties of the native and modified starches, however the objective of the present study was to investigate the compression, mechanical and release properties of thermal and chemically modified starches from Bambara nut in Ibuprofen tablet formulations as directly compressible and sustained release excipients. Ibuprofen was chosen as the model drug for this study because of it known poor compaction properties [25], in order to assess the influence of the starch-based excipients on the formed tablets. 2 Materials and methods 2.1 Materials Materials used include Ibuprofen powder B.P., sodium chloride (BDH Chemicals Limited), acetic anhydride (BDH Chemicals Limited), hydrochloric acid (BDH Chemicals Limited), magnesium stearate (Aldrich Chemical Company Inc., USA) and Acetone (Merck Limited, Germany). Other reagents were of analytical

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