It is a genetic disorder that is inherited from both parents who are carriers of the disease. It is characterized by anaemia with small and pale red blood cells (hypochromic microcytic anaemia) due to reduced production of one or more globin chains in the red blood cells. The consequences are ruptured of red blood cells in the spleen (Fucharoen, 1987; Weatherall, 1997). The clinical severity of thalassemia varies greatly depending on the number of genes affected (Cornelis, 2010). Approximately 7.0% of the world’s population is thalassaemia carrier and an estimated 300,000 babies are born each year with this disorder.
Disorders of complete blood count For a normal body homeostasis, the levels of the components of blood must attain within the normal range. When the levels of RBC, WBC, platelets and others go below normal, there is a deficiently and these leads to health issues and disorders. • Anemia When the level of red blood cells is decreased below normal, it means that your hematocrit and your hemoglobin levels are insufficient, this condition is known as anemia. Patients with anemia feel fatigue and tired all the time. Anemia is mainly causes by iron deficiency.
To our knowledge, our case is the youngest one who received a high dose of cisplatin (500 mg/m2) in the absence of intravenous hydration, and nephrotoxicity result in renal failure, hearing loss, visual impairment, severe myelosuppression complicated by life-threatening sepsis were presented in this patient. Although vigorous therapies were given, the patient decreased. As the toxicity of cisplatin is dose-dependent, early elimination of the drug from plasma should be critical in the management. Most of the platinum in the blood plasma is bound to proteins within a few hours after intravenous administration. Binding of cisplatin to proteins and enzymes is generally believed to be the cause of its side effects, especially ototoxicity and
DIARRHEA Definition and Overview Diarrhea is a medical condition where the patient has at least three loose or liquid bowel movements a day. It is one of the most common diseases experienced by any age group, and is especially common in children. The most significant complication of diarrhea is dehydration. Dehydration is a condition resulting from massive loss of body water and electrolytes. When diarrhea ensues, body fluid and electrolytes are eliminated by the body before they are adequately absorbed.
Children born with thalassemia major are normal at birth, but develop severe anemia during the first year of life. Other symptoms can include: Bone deformities in the face, fatigue, growth failure, shortness of breath and yellow skin (jaundice).Severe thalassemia can cause early death (between ages 20 & 30 years)
Diabetic retinopathy is a major cause of visual impairment in middle aged people and visual loss in older people. It affects almost all individuals who have had diabetes for more than fifteen years. It affects both Type 1 and Type 2 individuals. Diabetic retinopathy is hardly detected in the first few years of diabetes. It is the most common micro vascular complication of people with diabetes.
Progressive ataxia due to alpha tocopherol deficiency in Pakistan Introduction Ataxia is a common neurological symptom which is encountered in neurology practice. It has a multiple etiologies, among which vitamin E deficiency is a treatable and relatively reversible cause. Early diagnosis and replacement of vitamin E can alleviate the symptoms, halt the disease progression and can even reverse ataxia associated with it. It closely mimics Frederich's ataxia. Patients should be screened for vitamin E deficiency if workup for fredrich’s ataxia is negative.
I. What is a Hematocrit? A Hematocrit test measures the proportion of red blood cells in your blood. Red blood cells carry oxygen throughout your body. Having too few or too many red blood cells can be a sign that you have certain diseases.
An investigation of the relationship between different concentrations of Sodium Chloride and the rate of reaction of Amylase Marjolijn Hoogevoorst Yeshvanth Prabakar IS12 Word count: 2222 words Introduction: Enzymes are biological catalysts that speed up reactions by lowering the activation energy. Amylase is a type of digestive enzyme found in the pancreases and saliva of humans. Amylase breaks down starch into sugar, allowing large molecules to be digested easily. To function efficiently, amylase requires certain conditions. The effect of different sodium chloride concentrations in this on the rate of reaction of amylase will be investigated in this experiment along with the use of starch and iodine.
Alkalosis & Acidosis Shalita Johnson SC131 Respiratory Acidosis: This is a condition that occurs when the lungs cannot remove enough carbon dioxide that is produce by the body. When the body have excess carbon dioxide (CO2) this causes the pH of the blood and other body fluids to decrease, this make them acidic. This can be known as ventilatory and respiratory failure. Normal range: PaCO2 35-45 mmHg. pH levels are 7.35 to 7.45.