Biomaterial Advantages

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Bone is a remarkable organ playing key roles in critical functions in human physiology including protection, movement and support of other critical organs, blood production, mineral storage, homeostasis, blood pH regulation, housing of multiple progenitor cells like mesenchymal, hematopoietic and others (Porter et al., 2009). Though the bone houses a number of growth factors and acts as the only support and frame work of the organism, sometimes it still fails due to the exposure to injury caused by stress that ultimately leads to the breakage of bones. Human body is capable of repairing minor bone defects but when it comes to a critical sized bone defect, the repair is tedious. The classical and most widely used treatments for these defects…show more content…
Different biomaterials have different kinds of applications. Natural or synthetic polymers along with ceramic materials have been widely used (Swetha et al., 2010). In bone tissue engineering, an ideal biomaterial should be both osteoconductive and osteoinductive for effective tissue regeneration. Many biomaterials with osteoconductive or osteoinductive property or both have been identified and widely studied for their application in bone tissue engineering. But how these biomaterials influence the activities of the cells is still an area that has to be explored. Understanding the mechanism of action of biomaterials on cells would greatly help us in effective use of…show more content…
Biomaterials for bone tissue engineering possess a property to heal bone defects in vivo. They are chosen by studying a number of properties including bioactivity (osteo-conductive, osteo-inductive, osseo-integration), cell and tissue compatibility, and load bearing capacity. Any biomaterial considered should possess a structure to promote cell adhesion for the osteoblast, osteoprogenitor or stem cells. There are three major criteria to be noted when a biomaterial is taken for study other than those mentioned previously: (i) Composition - polymer, metals, ceramics etc; (ii) Stability -resorbable, non-resorbable; (iii) Purpose - load bearing, filling material (Schlögl and Winfried,

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