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Blood Clotting Research Paper

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INTRODUCTION

A thrombus or a blood clot is the final product of the blood coagulation which brings in hemostasis. Clotting is essential and it is life saving to arrest bleeding during trauma, surgery etc. it is well known when thrombus is not formed as in the case of hemophilic they can bleed to death. So that substantiates the necessity of clotting. However blood clots can also form abnormally obstructing the blood flow through the blood vessels causing myocardial infarction, brain stroke, gangrene of the extremities and other medical problems. Clotting disorders is a term used to describe a group of conditions in which there is an increased tendency for the blood to clot causing serious complications. Thrombophilia is the sub specialty in …show more content…

It affects a large number of people around the world. Recent research shows that these disorders contribute significantly to morbidity and mortality in the United States. Each year, more than 600,000 Americans die from abnormal blood clots 1. It is estimated that 60,000-100,000 Americans die of deep vein thrombosis or pulmonary embolism 2. Metal ions are required for many critical functions in humans. Scarcity of some metal ions can lead to disease. Well-known examples include pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency3. The effect of metal ions on the blood clotting is also diagnostically useful 4. The principal object of the present invention is to provide a method to rapidly assess the overall coagulant properties of a sample of a blood with the metal ions, and subsequently measuring clotting time by standard methods. The measurement preferably includes the clotting time of a control sample of whole blood without the addition of metal ion, to which the clotting time of the sample containing the metal ion is compared. The preferred metal ions are copper, …show more content…

Hospital Research and Post Graduate Centre, Chennai. The study was cleared by institutional ethical committees and proper informed consent was obtained from the participants in the study. A total number of 50 healthy volunteers in the age group of 18 – 35 years participated in the study (mean age 26.86, SD ± 3.85). Under aseptic precaution vein puncture is done and blood samples were withdrawn for studying the clotting time of blood using various metal salts such as copper sulphate, silver nitrate and gold chloride. 3 ml of blood was drawn and 0.5 ml was transferred into four test tubes. Tube - 1: serves as control (Saline + Blood), Tube – II: Blood + Copper sulphate solution, Tube – III: Blood + Silver nitrate solution,

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