Bupropion Research Paper

5. RESULTS AND DISCUSSION

5. RESULTS AND DISCUSSION

The present study was undertaken to formulate a extended release tablet dosage form containing a core tablet on which polymeric layers are coated which extends the release. These polymeric layers undergo different rates of swelling and drug release by diffusion process.

A) API Characterization:
Table 5.1: Organoleptic properties of Bupropion HCl
S.No. Properties Results
1 Description White powder
2 Taste and Odour Highly bitter & Odourless
3 Color Colorless

Inference:
By observing the Organoleptic properties, the given Bupropion HCl was found to be white powder, highly bitter, odourless and colorless.

Determination of melting point.
The melting point of the Bupropion HCl was determined

The standard graph constructed conferred that the concentrations of drug ranging from 6 to 16 µg/ml obeyed the beer lambert principle. Moreover, the calibration curve of Bupropion HCl exhibited a good correlation between the concentrations and the absorbance in this range (R2 = 0.999).

Solubility analysis
Solubility data of Bupropion HCl
Table 5.3
S.No. Medium Approximate pH Solubility
(mg/ml) Dose/solubility Ratio
1 0.1N HCl 1.2 310.36 0.966
2 pH 4.5 Acetate Buffer 4.5 1197.58 0.250
3 pH 6.8 Phosphate Buffer 6.8 273.78 1.095
4 pH 7.4 Phosphate Buffer 7.4 364.56 0.822
5 Purified water 6.02 272.97 1.099

Inference;From the above data it was observed that Bupropion HCl was soluble over the observed pH (1.2 to 7.4). DRUG- EXCIEPIENT COMPATIBILITY STUDY

Table No: 5.4Results of Compatibility study

S.No Name of the Excipient Ratio
API: Exp Initial Observation 50°C Final observation Conclusion 40°C/75% RH 2nd week 4th week
1 API (Bupropion hydrochloride) --- White ---- White White