Cancer Chemotherapy Case Study

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CHAPTER-1 INTRODUCTION 1.1 Cancer or cancer chemotherapy Cancer is abnormal growth of cell division that has potential to spread to other body cells. There are two types of cancers. One is the benign cancer don’t spread to other body cells and malignant cancer can spread to other body cells. Cancer chemotherapy is the branch of medical oncology and used for the treatment of cancer. The principle of chemotherapy is that by using of chemotherapeutic agents or drugs, cancer cells can be removed. These drugs or chemotherapeutic agents act at the cancer cells and controlled the process of cell mitosis but they can produce toxicity.1 1.2 Cell Cycle The series of events in which one cell undergoes in process of division and accomplished in an individual called cell cycle. There are number of phases in cell…show more content…
The ruthenium II complex [Ru(II)(η6-arene)(en)X]+ and ruthenium III complex Na[Ru(Im)(Me2So)Cl4] showed the metastatic anticancer activity. Ru (III) complexes are biologically inert than Ru (II) complexes because the Ru(II) complexes are reactive towards the DNA reaction than Ru(III). So, Ru (III) first convert into Ru(II) and then showed the anticancer activity. In 2009, Ansari et al. prepared the complexes of Mn(III) that showed the antitumor activity in human cancer cells through apoptosis method. Lanthnum complexes are also used for the treatment of cancer cells. Gold complexes also showed the antitumor activity but the mechanism of action is different than cisplatin because in cisplatin the target cell is DNA but in gold complexes, the target cell is mitochondria. The 2-[(dimethylamino) methyl] phenyl gold (III) complex showed the anticancer activity against the cancer cells of human. For the specific damage of cancer cells, gold nano-particles showed the better anticancer activity combining with

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