In-vitro dissolution test of the optimized liquisolid orodispersible formula (F18) was significantly higher than DCT and marketed tablet . 12. The in vivo pharmacokinetic study suggests that the optimized formula F18 developed in this work may be useful for the treatment of acute migraine attack due to the enhanced dissolution rate and by passing hepatic first pass metabolism through the partial absorption from buccal mucosa. 13. Based on these results, it could be concluded that a promising quickly absorbed liquisolid orodispersible tablets of Zolmitriptan were successfully designed for treatment of acute migraine attack.
N-arylsulfonyl tryptophanderivatives were investigated as ligands for the reaction due to “the high π-electron-donating characterof the indole ring” (? )B-n-butyloxazaborolidine was used at 5 mol% to accelerate and control the reaction of cyclopentadiene and 2-bromoacrolein (-78 °C) in DCM. Enantioselectivity of the desired 2R adduct occurred at ca. 200:1 with a high yield. This catalyst can be used to enantioselectively produce gibberellic acid, a plant hormone, as well as the antiulcer agent, cassiol and eunicenone.
Specifically, this investigation analyses how the initial temperature effects the rate of Hydrogen Peroxide oxidising Potential Acid Sulfate Soil. Only when a rapid reaction took place, PASS has been oxidised using Redox theory with the presence of pyrite or other sulphides to react. The hypothesis that the rate of oxidation is correlates with the initial temperature of the solution is true, with the theory being supported that the higher temperatures result in increased reaction speed. This lab test was conducted over two different depths of PASS, with three trials of five temperatures for each of the two depths. The first and most obvious form of evidence lays within the averaged pH levels over time.
Several methods used for determination of GT including colorimetric [2,3], amperometric enzyme-immunosensors , flow injection chemiluminescence , spectrofluorometry [6,7], capillary electrophoresis with UV detection , liquid chromatography (LC) [9–14] and high performance liquid chromatography (HPLC) [15–23]. Kinetic methods have many advantages over other spectrophotometric methods due to their high selectivity and elimination of
The substituents should therefore be hydrophobic and electron donating for maximum activity. • log 1/C is the concentration of drug that has a defined biological activity. The bigger the value of log 1/C , the smaller the value of c, the better the drug. • P is a measure of overall hydrophobicity. • π is the substituent hydrophobicity constant and measures the hydrophobicity of a specific region on the drug’s skeleton.
This reaction was able to happen during designated lab time due to the fact that a phenol was used. Phenols or more reactive than unsubstitued benzene rings due to the presence of the alcohol on the benzene ring. The alcohol is considered an activating group due to the oxygen’s ability to donate its lone pairs into the benzene ring thus giving it more electrons and thus making it more nucleophilic and more likely to react with the introduced electrophilic species. As aforementioned, there are various products formed in this reaction the two major products formed though are the ortho and para products. It is debatable which product is more prominent due to steric reasons and the capability of each product to conduct in hydrogen bonding.
The difference between the rates of the reaction’s when 1 mole was inserted, and when the 3 mole was inserted is 118.49 seconds. This is the data the proves that my hypothesis is correct, this is because as the amount of mole increase, the amount of energry included in the reaction is more. for example, take the 1 mole of HCL, the 2 mole of HCL, and the 3 moles of HCL. The 1st mole of HCL has more particles than the 2nd mole of HCL, and thus when the 1st mole reacts with HCL, the rate of the reaction will be more because there will be more less energy in the reaction of HCL and Mg, compared to the 2nd mole of HCL and it reaction with Mg, (the 2 moles of HCL has more energy than the 1 mole), so hence, there will be more energy in the reaction . Both mole of HCL(the 2 moles of HCL and the 1 mole of HCL) have less energy , and thus when the 3 moles of HCL reacts with Mg, there is even more energy between the Mg and the HCL particles, so hence the rate of the reaction will be faster.
Abastract The intermolecular interactions between halo-cyclopropenone derivatives (HC3OX;X= F, Cl, Br and I) and hypohalous acids (HOY; Y=F, Cl, Br and I) were investigated using the MP2 method with aug–cc-pVTZ basis set. Three types of complexes are forming by:1) hydrogen bond, 2) both hydrogen and halogen bonds, 3) halogen bond interactions. The results indicated that interactions in type 1 complexes are stronger than those in types 2 and 3. The H–O bonds show red shifts with complex formation in types 1 and 2, in which they are more considerable for type 1 complexes. The O–Y bonds display red shifts in the type 3 and blue shift in the type 2 complexes.
There are some of the most useful nonsteroidal anti-inflammatory drugs (NSAIDs) are structurally derived from arylacetic acids. These compounds are often referred to as the “profens” based on the suffix of the prototype member, ibuprofen. These agents are all strong organic acids (pKa = 3-5) and consequently form water soluble salts with alkaline reagents. All of these compounds are mostly ionized at physiologic pH and more lipophilic than ASA or salicylic acid. In order to increases cyclooxygenase inhibitory activity and reduces toxicity of the profens, the α-CH3 substitutent present in the profens.
Few thousands of pounds per square inch must be pressurised in order to obtain a satisfactory flow rate. Diffusion is the process by which the rate of distribution of drugs between stationary and mobile phase is controlled. A faster and effective separation can be achieved if the diffusion is minimized. When compared to classical column chromatography high performance liquid chromatography is so called because of its improved performance. Due to high-pressure pumping system and sensitive detectors have transferred liquid chromatography into high speed, accurate, efficient and highly resolved method of