Castleman's Disease Research Paper
Castleman’s Disease Immune System
Castleman’s disease, also known as giant lymph node hyperplasia and CD, is a rare disorder that involves an overgrowth of cells in your body’s lymphatic system. It was first described by Dr. Benjamin Castleman in 1950. CD is not a form of cancer but is called lymphoproliferative disorder, which means there is an abnormal growth of lymphatic cells and is similar to cancers of the immune system. Although it may not be a type of cancer one of the two forms, called multicentric Castleman’s disease, acts just like lymphoma. Many people with multicentric Castleman’s disease actually develop lymphomas.
The two types of castleman’s disease are localized and multicentric which affect people very differently.
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This form can also start to form in people with HIV, and in these people the disease is more dangerous and serious. Patients with MCD can contract a serious infection, fevers, weight loss, fatigue, numbness, night sweats, anemia, high numbers of antibodies in the blood, and nerve damage. The infection that may occur may stay for a long period of time because the immune system is failing. Also lymphoma is easily developed and is quite hard to dispose of. Infections have great influences on developing Castleman’s disease. There are two types of multicentric and they are caused whether with HIV positive or …show more content…
The most common cytokine is IL-6, but in some cases the level of IL-6 is normal and is present with non-iron-deficient microcytic anemia. The release of IL-6 is caused by HIV-8, some studies suggest that cytokines are released by a mutation. HIV-8 is also capable in causing cancerous tumors in the blood vessels. Besides the circulatory system no other body system is affected bys Castleman’s disease. Castleman’s disease can affect anyone most diagnostics are around the age of thirty five. The only cause that is most likely to be responsible for Castleman’s disease is HIV/AIDS. With AIDS the outcome becomes worsened. Patients with POEMS syndrome and multicentric Castleman’s disease have bone lesions seem to do better. Castleman’s disease is just as common as
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