Cavia Cobaya Model

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Relapse in cavia cobaya models occurs rapidly. The left first insisivus compressed towards the distal side during 14 days orthodontic tooth movement and relapsed toward the mesial side. There was a rapid relapse initially following 2 days appliance removal Increasing osteoclast activity in tension side show that the number osteoclast situated along the alveolar bone mesial of insisivus at the end of active treatment. Decreasing osteoclast activity by applying Stichopus hermanii during relapse period means bone remodeling begins. Periodontal ligament plays a central role for remodeling periodontal ligament dan alveolar bone. Stichopus hermanii contain various active ingredient such as hyaluronic acid,chondroitin sulphate,cell growth factor, EPA DHA, flavonoid. 7 Stichopus hermanii propose a potent anti-osteoclastogenic effect because of hyaluronan effect. The anti-osteoclastogenic function of hyaluronan was dependent on Toll-like receptor 4 (TLR4) but not on CD44. Hyaluronan inhibited Macrophage Colony Stimulating Factor (M-CSF)-dependent signaling pathways involving Rac, reactive oxygen species and mitogen-activated protein kinases, resulting in suppression of transcription factors AP-1 and MITF that…show more content…
7 Previous studies showed that the water extract of Stichopus contains high amino acid concentrations (37%)34 as well as calcium, magnesium, iron and zinc. Collagen itself have function to modulate the formation of bone matrix in osteogenesis.9 The effect of glycosaminoglycan (GAG) such as chondroitin sulphate, oral administration had been shown to increase the total calcium pool and intestinal absorption of calcium, which may lead to an increased capacity for injured bone to regenerate during osteogenesis. 9 Condroitin Sulphate on the surface of bone matrix binds to cell adhesion molecule such as integrin.

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