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Characteristics Of Biopharmaceuticals

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Biopharmaceuticals are medical drugs that are produced using biotechnology. They are proteins (antibodies) and nucleic acids (DNA, RNA or antisense oligonucleotides) used for therapeutic or in vivo diagnostic purposes, and are produced by means other than direct extraction from a native (non-engineered) biological source. Insulin is the first biopharmaceutical product. The production of biopharmaceuticals has globally increased significantly over the last decade. Biopharmaceuticals make up about one-third of drug currently in development and refer to pharmaceutical substances derived from biological sources. These medical drugs produced using biotechnology especially genetic engineering or hybridoma technology or through biopharmaceutical techniques …show more content…

Biopharmaceuticals are produced within living cells and in most cases, they are proteins. Besides that, they are also known as macromolecules due to the large molecular weights. As biopharmaceuticals have very large molecular weights, they are structurally very complex. Other than that, they are also highly sensitive to environmental factors such as temperature. This is because of their large sizes and structural complexity. Most of the products needed to be stored at low temperature as low as 2-8 ℃. This is to ensure the structural integrity. Macromolecules and proteins tend to be heterogeneous in nature, which means that multiple forms of the same protein often co-exist in any given formulation. These variants are called isoforms. This causes the biological drugs even at the end of the formulation process tend to be of mixed composition as opposed to a single distinct protein. The efficacy and safety will be affected when the composition or the ratio of these isoforms undergo …show more content…

It includes protein and nucleic acids. It is used for therapeutic. Most of the products are pharmaceuticals that are derived from life forms. The examples of biopharmaceutical products are enbrel and humira. Ebrel is usually used to cure people with an immune disease likes psoriasis and rheumatoid arthritis while humira is functioning in reducing the signs and symptoms of moderate to severe rheumatoid arthritis. This product is usually used by adults. Besides that, remicade and gardasil are also examples of biopharmaceutical products. The signs and symptoms of Crohn's disease can be reduced by using remicade while gardasil is a vaccine that helps in guarding against diseases caused by human

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