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Chemical Synthesis Essay

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Nofal et al synthesized a series of 1-(1H-benzimidazol-2-yl)-3-(substituted)-2-propen-1-one (Scheme 6). Claisen-Schmidt condensation of 2-acetylbenzimidazole and 2-acetyl-1-methylbenzimidazole led to the formation of 1-(1H-benzo[d]imidazol-2-yl)-4-(3,4,5-trimethoxyphenyl)but-2-en-1-one which on condensation with hydroxylamine hydrochloride in 5% ethanolic sodium hydroxide yielded 2-(4,5-dihydro-5-(3,4,5- trimethoxyphenyl)isoxazol-3-yl)-1H-benzo[d]imidazole. Some of the selected synthesized compounds were evaluated for their anticancer potential in the two cell lines, HEPG2 (human liver carcinoma cell line) and PC12 (pheochromocytoma of the rat adrenal medulla). Acetaminophen, a known hepatotoxin used as positive control, was tested at concentrations

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