Chitosan Case Study

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ABSTRACT The purpose of this study was to investigate the efficiency of silicated chitosan in promoting tablet disintegration and drug dissolution in comparison with commonly used superdisintegrant crospovidone. Silicated chitosan was prepared by co-precipitation method and metoclopramide hydrochloride was used as a model drug for the preparation of fast dissolving tablets. Formulations containing silicated chitosan exhibited almost similar in-vitro dispersion time and in-vitro drug dissolution pattern in comparison with formulation containing crospovidone. The intimate physical association between chitosan and silica creates an insoluble, hydrophilic, highly absorbent material, consequently, resulting in superiority in water uptake, water saturation for gel formation and compatibility. IR spectroscopic studies of silicated chitosan, silica, chitosan and chitosan-silica physical mixture indicated that preparation method did not involve any chemical reaction and only physical modification occurred on chitosan particles. Short-term stability studies on this formulation indicated that there were no significant changes in drug content and in vitro dispersion time (p<0.05).…show more content…
It can be concluded from the present work that silicated chitosan acts as a superdisintegrant at all the concentrations and exhibits similar performance in comparison with crospovidone used in MTH fast dissolving tablets. ACKNOWLEDGEMENTS The authors are thankful to M/s Comed Chemicals Ltd, Baroda (India) for providing gift sample of metoclopramide hydrochloride. They also wish to express their gratefulness to the Principal, HKES’s M T R Institute of Pharmaceutical Sciences, Gulbarga for providing the necessary facilities for the

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