Abstract Liquisolid systems is an innovative technique for enhancing solubility, dissolution and bioavailability of poorly water soluble drugs. It involves changing of the drug in the liquid state into compressible and freely flowable dry powder throughout its absorption into appropriate porous carrier (e.g.microcrystalline cellulose), after that the powder coated with material has a highly adsorption capacity (known as colloidal silica). Orally disintegrating tablets represent a novel dosage form that overcomes the difficultiess of swallowing and provides a fast onset of action. Zolmitriptan is a slightly soluble drug used for treatment of acute headache of migraine; it's known to suffer from first pass effect with bioavailability of 40 %. The aim of the present work was to formulate Zolmitriptan as orodispersible tablets
Background: Adjuncts to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Midazolam, a water-soluble benzodiazepine, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. Aim: Study was to assess the effect of Midazolam added to brachial plexus block by supraclavicular approach. Materials and Methods: A prospective, randomized, single blinded study was conducted on 100 ASA Grade I or II adult patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were randomly divided into two groups.
CHAPTER 4 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH PDA DETECTOR FOR COMBINED DETERMINATION OF EMTRICITABINE, TENOFOVIR AND EFAVIRENZ The present work describes a simple assay method for determination of emtricitabine, tenofovir and efavirenz in their combined tablet dosage form by using HPLC with PDA detector. Our aim was to develop a simple, accurate, sensitive method for simultaneous determination of emtricitabine, tenofovir and efavirenz in combined pharmaceutical dosage form by HPLC with UV detection, where simple mobile phase composition was used for chromatographic separation without any ion-pairing agent. Total retention time for analysis was short with a good resolution between emtricitabine, tenofovir and efavirenz. All these reasons make this new method was really lucrative. This method was also validated for linearity, accuracy, precision, selectivity, sensitivity and degradation studies according to the ICH guidelines.
The release profile of formulation F4 showed peppas kinetics. Other formulation showed Matrix kinetics. Except for optimized formulation F4 (r2 = 0.9808), all other formulations were governed by diffusion mechanism. Stability studies There were no significant changes in terms of physical characteristics, drug content, tensile strength and in vitro permeation rate and patches were found to be physically and chemically stable after 30 and 60 days at different storage conditions.
Figure 15: FTIR spectra of pantoprazole sodium+kollicoat MAE 30DP Drug-excipient compatability studies: FTIR In the FTIR spectra of pure drug and different polymers it is observed that the peaks of major functional groups which are present in spectrum of pure drug are observed in combination of drug and polymers. There was no appearance or disappearance of any characteristics peak in the FTIR spectrum of Optimized formulation. This shows that there is no chemical interaction between the drug and the polymers used .The presence of peaks at the expected range confirms that the materials taken for the study are genuine and there were no possible interactions occurred. 7.1.2 PREFORMULATION CHARACTERISTICS Table 23: Preformulation of powder blend of pantoprazole sodium core tablet Formulation code Angle of repose Bulk density (gm/cm2) Tapped density (gm/cm2) Hausners ratio %compressibility C1 25.7±0.03 0.34±0.02 0.42±0.03 1.24 19.04±0.01 C2 26.8±0.01 0.36±0.02 0.45±0.05 1.26
((Love J). sodium picosulphate in combination with magnesium citrate has synergistic effects. As mentioned earlier, sodium picosulphate has purgative actions, while magnesium citrate (osmotic laxative) reacts with water thereby retaining fluids in the colon. By these dual mechanisms sodiumpicoslphate/magnesium citrate exerts its bowel cleansing effects. Various clinical studies evaluated its efficacy in comparison with other bowel preparation agents: • In a randomized, multicentre, assessor-blinded, prespecified non-inferiority, head to head study, bowel cleansing effects of sodium picosulphate/magnesium citrate were compared with that of 2L polyethylene glycol solution and two 5-mg bisacodyl tablets.
ABSTRACT Floating bioadhesive tablets of hydrochlorthiazide were developed to prolong gastric residence time leading to an increase in drug bioavailability. Tablets are prepared by direct compression technique using polymers Xanthum gum, Chitosan, Eudragit L- 100, Magnesium stearate USP-NF (Avicel PH 102), Microcrystalline cellulose Ph 102, Talc, Microcrystalline cellulose Ph 102 and sodium bicarbonate. Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability and weight variation, drug content and floating properties. Gas generating agent plays an important role in floating lag time and drug release. The best formulation subjected for kinetic treatment.
Keywords: Ketoconazole, Antifungal agents, Optimization, Baker Lonsdale model, Peppas model, Higuchi plot INTRODUCTION The main objective was to design diffusion controlled microsphere drug delivery system of ketoconazole in order to sustain the delivery of the drug and thereby reduce the gastrointestinal disturbances and dose related adverse effects like hepatic dysfunction and allergic reactions as observed with conventional oral dosage form of ketoconazole (tablet). Ketoconazole microspheres prepared using dichloromethane, one of the class II solvents proposed in ICH guidelines (Q3C) to be used in the pharmaceutical industry because of their low toxic potential, as the coacervating agent to reduce residual solvent. MATERIALS
Aim:2 Expanding the Application of Conductive Polymer for Solid Phase Extraction 2.1 (New Direction) Application of Polypyrrole based Conductive Polymer Coating Material for Extraction, Determination and Quantification of Active Ingredient in Personal Care Products 2.1.1 Introduction Triclosan is commonly used in personal care and household products such as shampoo, toothpaste, soaps, detergents, skin care creams and lotions because of its antimicrobial properties. As per US food and drug agency (USFDA) the typical concentration of triclosan should not exceed 0.3% (w/w) of product weight42. The reports suggest that triclosan is transported to municipal wastewater treatment plants through domestic sewage and finally discharged in aquatic environment from wastewater effluent43. The
Hence, Tween 20 was selected as Surfactant for enhancing drug loading capacity. Co-surfactants were selected based on their ability to form stable and clear microemulsion at a minimum concentration. Based on this, several co-surfactants like Polyethylene Glycol 400 (PEG 400), Glycerol, Polyethylene Glycol 600 (PEG 600), Isopropyl alcohol and Isobutyl alcohol were screened. From that, PEG 400 was selected as gave transparent and clear microemulsion at low concentration. Solubility of drug in PEG 400 was checked and it was found to be 3.23 mg/ml.