Individual Application: Cholesterol
a) The shape of cholesterol is that it’s composed of three different fragments, a hydrocarbon tail, four steroid (hydrocarbon) rings, and a hydroxyl group. Since the hydroxyl group is polar, and the hydrocarbon rings and hydrocarbon tail are non-polar, it makes the molecule amphiphilic. The size of cholesterol varies between what types of cholesterol that is being observed. The two types of cholesterol found in the blood are low-density lipoprotein (LDP, the ‘bad’ one) and high-density lipoprotein (HDP, the ‘good’ one). Also, there are two types of LDP cholesterol particles, type-B, which are small and dense, and type-A, which are large and fluffy. Moreover, HPD is smaller than, LDP but with a more complex
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Firstly, it influences cholesterol’s solubility because of its polarity. Since the hydroxyl group is polar, it allows this portion of the molecule’s structure to be able to dissolve in water, causing cholesterol to be an alcohol. Overall, the molecule is amphiphilic because the hydroxyl group allows cholesterol to be hydrophilic, and the presence of its other structural features causes it to be hydrophobic. Secondly, the hydroxyl group influences cholesterol’s reactivity because it’s what causes the molecule to be very reactive, since the hydrocarbon tail and hydrocarbon rings are not as reactive. Thirdly, the hydroxyl group influences the cholesterol’s physical shape because its presence makes cholesterol a steroid alcohol. Also, it acts as a pivot point around which the molecule tilts. Furthermore, some researchers also discovered the presence of cholesterol’s hydroxyl group to not be at the end, but in the middle of a polyunsaturated lipid membrane. This seems to be caused by the polyunsaturated lipid membrane’s incapability to be in close proximity with cholesterol’s usually hydroxyl position. Lastly, the hydroxyl group influences cholesterol’s overall function because it helps the molecule regulate the membrane. It does this by cooperating with the membrane phospholipids and sphingolipid’s’ polar head …show more content…
Cholesterol is found in every one of the cells in the body, and without the presence of this molecule, the body will not be able to function because it need certain amounts of cholesterol to survive. Firstly, this molecule is located in the ovaries and testes, where it is converted to steroid hormones. These steroid hormones play a key role in helping the human body function, thus the absence of these hormones can cause malfunctions with weight, bone health, mental status, etc. Secondly, cholesterol helps the liver to make bile which helps human beings digest their food. Without the production of bile, humans are unable to digest foods, mainly fats. If this occurs, the undigested fat will get into the bloodstream causing the arteries to be blocked, which can lead to heart attacks. Finally, cholesterol are one of the main components that make up the structure of the cells in the human body. Its role is to provide a protective barrier. Also, cholesterol needs to be kept at certain quantities, thus if an alteration in the quantity of cholesterol occurs, the cells become affected, which can impact the ability for humans to metabolize and produce
In Chromosome 11 titled Personality, I found it fascinating to learn that our cholesterol plays a role in our disposition. Cholesterol plays a big role because there was found to be a correlation between it and serotonin. During an experiment where mice were fed low cholesterol diets, they became more aggressive and bad tempered. The cause seemed to be a drop in serotonin levels. (pg.170) Dopamine and Serotonin are both
While physical activity also helps incres HDL chalostral levels. Because there are so benifiests to physical activy not being active leads to pooor colostral levels and weak heart muslces
LDLR play a significant role in cholesterol homeostasis, in which it allows the shuttling of LDL from the bloodstream to nearby cells to control cholesterol levels in the human body (Mousavi, et al., 2009). When there is a dysfunctional mutation in this receptor, its function for clearing out the LDL will
It is important to control plasma lipid levels because a decrease in plasma concentration of LDL-cholesterol can decrease the risk of coronary heart disease. Cholesterol is transformed to bile acids in the liver. Then, the bile acids are excreted into the intestine, where they are reabsorbed. Cholestyramine is a large, insoluble, and positively charged resin, which binds to the negatively charged intestinal bile acids and prevents their reabsorption. The resin also increases the excretion of these bile acids, which leads to the increased
INTRODUCTION Palm oil industry is an industry that produces various things with palm oil, such as chocolate, chewing gum, lipstick, soap, biodiesel, etc. Palm oil can be beneficial and problematic towards us. What most people know the benefits of palm oil is that, it is good for your health; reduce risk of having heart diseases and it can increase our “good” cholesterol which is the HDL (High-Density Lipoprotein) cholesterol. High-density Lipoprotein means that it is preservative.
When you have fewer fats, your body is saved from various harmful diseases such as diabetes, coronary heart disease and cholesterol. This helps to increase your quality of life and also gives you longevity. This might seem difficult
In the study, it emphasizes how high cholesterol impacts the health of rats with a decrease in ATP production, increase of lactate levels, and increase of oxidative stress in myocardium, and this increases the risk of developing cardiovascular disease, known as ischemic heart disease. Avoiding cholesterol completely may harm the body, because cholesterol is needed to produce cell membranes, is the precursor of for the synthesis of hormones and Vitamin D. Part of maintaining these levels is by performing fasting lipoprotein profile test that checks for the LDL (low density lipoprotein) cholesterol, HDL (high density lipoprotein) cholesterol, and the levels of triglycerides in the blood. These levels should remain in the standard ranges based on gender, weight, age, etc. The treatment of this condition will not be discussed in the study, but one may choose to improve their diet or count on drugs specifically HMG CoA reductase inhibitors that reduce the levels of cholesterol and triglycerides in the
Fat-O-Phobia This was an interesting point made in the reading, it outlines how today we are in a way scared of fat and try to avoid it at all cost. Ratey pointed out that cholesterol is thought to be the main reason for most heart diseases “Dietary cholesterol, for instance, has an insignificant effect on blood cholesterol. It might elevate cholesterol level in a small percentage, but for most of us, it’s clinically meaningless” (Ratey, 2015, p. 83).
For the cardiovascular step test, the class broke up into groups of four. Each member was given a specific role within the group. One person represented the Active participant, or Treatment #1. Treatment #2 represented the person who was non active. One person in the group controlled the stop watch at 3 minutes, while another recorded the results after that time frame.
In the experiment, I thought that running in place would raise your heart rate, and that proved to be true. In our experiment group members ran in place for five minutes and took their heart rate every minute, and at the end of five minutes every group member’s heart raise rose. After five minutes one group member’s heart rate rose from 100 beats per minute to 176 beats per minute, an increase of 76 beats per minute. Another group member had their heart rate raise from 60 to 88 beats per minute, an increase of 28 beats per minute.
The name liposome is derived from two Greek words: 'Lipos' meaning fat and 'Soma' meaning body. A liposome does not necessarily have lipophobic contents, such as water, although it usually does. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Liposomes can be prepared by disrupting biological membranes, for example by sonication. Liposomes are micro particulate or colloidal carriers, usually 0.05- 5.0 μm in diameter which form spontaneously when certain lipid are hydrated in aqueous media.
ALA are present in significant amounts and composition in brain and visual tissues, DHA is the main component of the cell membrane phospholipid structure for nerve cells and cell membrane while EPA is an essential building block for eicosanoids, a localized hormone which is important in nearly every development in our body hence very vital for infants and children below age of five. Linolenic acid produces both n-3 and n-6 fatty acids, the
Experiment #7: Column Chromatography of Food Dye Arianne Jan D. Tuozo Mr. Carlos Edward B. Santos October 12, 2015 Abstract Column chromatography is the separation of mixture’s components through a column. Before proceeding with the column chromatography itself, a proper solvent system must be chosen among the different solvents. The green colored food dye is the mixture whose components are separated.
Among them 20 are normal healthy individuals and 20 are patients with OSCC. Informed consent was obtained from the patient before sample collection. 5ml of fasting venous blood was collected and centrifuged in 3000rpm for 10 minutes. Then serum was separated and then it is analysed for serum cholesterol by Cholesterol esterase-Oxidase method, Serum triglycerides by colorimetric enzymatic method, HDL-c by Phosphotungtic acid method, LDL-c and VLDL-c were calculated by Friedwald’s formula. Results: There is a significant increase in LDH (p<0.005) levels in OSCC patients when compared with healthy controls, by the influence of OSCC on LDH metabolism.
Cholesterol is a soft, waxy substance that's stored in the fat (lipid) content of one's blood stream. It's actually important to have a certain amount of "good" cholesterol in one's system. Cholesterol, and our other body fats, cannot dissolve in our blood. They must be transported by special carriers called lipoproteins. While there are numerous kinds (too many to cover here), the two that are most important are the high-density lipoproteins (HDL) and the low-density lipoproteins (LDL).