Click Chemistry Reactions: An Experimental Study
Several protocols were used throughout the extent of the experimentation, such as during the development and purification of the organic complex. In the developmental phase of the organic complex, traditional methods of cycloaddition reactions were studied and analyzed to provide a basic understanding of a possible design for a practical reaction with cyclooctyne, The characteristics of Click Chemistry reactions were also studied and aided the experimental design of this project. The methodology of the experimentation was a slow-addition of cyclooctyne to a refluxing tricarbonyl iron(0) vinylketene complex in distilled hexane and ether. The purpose of this design was to lower the rate of trimerization of cyclooctyne and increase its reactivity
Triphenylethanol Synthesis Lab Report
1804 Words | 8 PagesMany sources of error were responsible for recovering a small amount of product. Introduction: The carbon-carbon bond formation is an important tool in organic chemistry to construct the simple as well as an organic compound. There are several
Analysis Of E-Stilbene Lab Report
1073 Words | 5 PagesThe hypothesis was supported by the employed methods. Introduction: This experiment was performed to show how bromination of alkenes reacts, and to be able to successfully synthesize meso-stilbene dibromide. The reaction of bromine with alkenes is an addition reaction where the nucleophilic double bond attacks the electrophilic bromine
Grignard Reaction Lab
397 Words | 2 PagesGrignard is a reaction that is crucial to forming the new carbon-carbon bond. This is a two-part lab that teaches new techniques; the purpose of this lab is to introduce realistic organic synthesis and apply acid workup to produce triphenylmethanol. A Grignard reaction is characterized by the addition of a magnesium halide (an organomagnesium halide) to an aldehyde or a ketone in order to form a secondary or tertiary alcohol. These reactions are helpful because they serve as a crucial tool in performing important carbon-carbon bond-forming reactions (Arizona State University, 2018). This experiment aimed to observe the mechanisms of a Grignard reply to synthesize triphenylmethanol from benzophenone using phenylmagnesium bromide as the Grignard reagent.
Diels-Alder Reaction Lab
999 Words | 4 PagesThe Diels-Alder reaction, an electrocyclic reaction between a conjugated diene and a substituted alkene, also known as a dienophile, was used in the experiment. The purpose was to synthesize a substituted cyclohexene derivate by the reaction between the diene and dienophile, and it reacted in a reflux solution with toluene as the solvent forming an unsaturated six-membered ring. First, approximately 54 mg each of both compounds, tetraphenylcyclopentadienone (TPCPD) and diphenylacetylene (DPA), were placed in a reaction tube to be mixed and heated on a sand bath for several minutes. During the heating process, the color of the TPCPD reactant would fade as the color went from purple to white showing the other reactant. Also during the heating, DPA refluxed for a brief time until the tube was removed from the sand bath for the melted product to cool and solidify.
Bromohexane Lab Report
1111 Words | 5 PagesThe goal of the experiment is to synthesize a bromohexane compound from 1-hexene and HBr(aq) under reflux conditions and use the silver nitrate and sodium iodide tests to determine if the product is a primary or secondary hydrocarbon. The heterogeneous reaction mixture contains 1-hexene, 48% HBr(aq), and tetrabutylammonium bromide and was heated to under reflux conditions. Heating under reflux means that the reaction mixture is heated at its boiling point so that the reaction can proceed at a faster rate. The attached reflux condenser allows volatile substances to return to the reaction flask so that no material is lost. Since alkenes are immiscible with concentrated HBr, tetrabutylammonium bromide is used as a phase-transfer catalyst.
Hydrolysis Of T-Butyl Chloride Lab Report
1766 Words | 8 PagesAims of experiment • Determine the rate constants for hydrolysis of (CH3)3CCl in solvent mixtures of different composition (50/50 V/V isopropanol/water and 40/60 V/V isopropanol/water) • Examine the effect of solvent mixture composition on the rate of hydrolysis of (CH3)3CCl Introduction With t-butyl chloride, (CH3)3CCl, being a tertiary halogenoalkane, it is predicted that (CH3)3CCl reacts with water in a nucleophilic substitution reaction (SN1 mechanism), where Step 1 is the rate-determining step. The reaction proceeds in a manner as shown
Preparation Of L-Phenylalanine Lab Report
802 Words | 4 PagesLecturer Date Introduction Theoretical Background Procedure The procedure was segmented into two categories, the reaction set up and the crude product isolation. Reaction set up The magnetic stirrer was prepared through placing it in the fume cupboard. 1 mmol of L-Phenylalanine was placed and weighed in a 5 mL conical vial.
Lab Report Scaffold: Bromination Of Trans-Cinnamic Acid
904 Words | 4 PagesChem 51 LB Experiment 3 Report Scaffold: Bromination of Trans-Cinnamic Acid 1. The goal of this experiment was to perform a halogenation reaction through the addition of two bromides from pyridinium tribromide. This was accomplished by reacting trans-cinnamic acid with pyridinium tribromide. After the reaction took place, melting point analysis was conducted to find out the stereochemistry of the product, which could either be syn-addition, anti-addition, or syn + anti-addition. 2.
Grignard Reaction Lab Report
1105 Words | 5 PagesDiscussion The purpose of this lab was to properly prepare a Grignard reagent from an unknown aryl halide and then to use the prepared Grignard reagent with solid carbon dioxide and an acid quench to form a carboxylic acid. Organometallics are compounds that have a carbon bonded to a metal; C-M, where M is any transition metal. In an organometallic, the carbon has a partial negative charge and is considered electron-rich due to the bond with the positively charged metal. Because of this partial negative charge, the carbon acts as a nucleophile and is able to be used in reactions to produce new bonds between carbon atoms by attaching to another carbon that acts as an electrophile.
Nucleophilic Substitution Reactions Lab
1039 Words | 5 PagesExperiment 2 Report Scaffold (Substitution Reactions, Purification, and Identification) Purpose/Introduction 1. A Sn2 reaction was conducted; this involved benzyl bromide, sodium hydroxide, an unknown compound and ethanol through reflux technique, mel-temp recordings, recrystallization, and analysis of TLC plates. 2. There was one unknown compound in the reaction that was later discovered after a series of techniques described above.
Methyl Trans-Cinnamate Lab Report
1399 Words | 6 PagesIt is understood the mechanism is acid-catalyzed where protons coordinate with the carbonyl oxygen to make the carbonyl carbon more electropositive for nucleophilic attack (Scheme 1). In the experimental procedure all reactants were added together, this is inefficient as the protons can coordinate with either trans-cinnamic acid or methanol. Coordination with methanol is unnecessary as it reduces its nucleophilicity and makes less protons available to coordinate with the carboxylic acid. To improve
Diels Alder Reaction Lab
672 Words | 3 PagesThe purpose of this lab is to use the Diels-Alder reaction to combine anthracene and maleic anhydride. Named after its two founders the Diels-Alder reaction is the addition of a conjugated diene (electron rich compound) with a dienophile (electron poor compound). (1) These compounds will be combined using [4+2] cycloaddition, where the numbers 4 and 2 come from the number of π electrons that are used in each compound to synthesize the product. (2) This experiment comes at the cost of losing two π bonds to form two new sigma (σ) bonds in the cyclic compound. (2)
Diels Alder Reaction Essay
502 Words | 3 PagesOne of the most used methods for the formation of six-membered rings is using the reactions of 1,3-diene with an alkene. The Diels-Alder reaction is a unique reaction in organic chemistry because it is a cycloaddition reaction. The Diels-Alder reactions are also known as 1,4 addition reactions due to the formation of new carbon-carbon σ bonds and π bonds. Electron-withdrawing groups like cyano (C≡N) and carbonyl (C=O) to increase the reaction rates and reaction yields (1). Often times there are no side reactions that occur during the Diels-Alder reactions.
How Can Cyclooctyne Effectively Reaction With A Vinylketene Complex
131 Words | 1 PagesThe major research question of my studies is if cyclooctyne can be successfully reacted with a vinylketene complex using a cost-effective methodology and in producing a distinct organic complex. In this experiment, a tricarbonyl iron(0) vinylketene complex was reacted with cyclooctyne in a cycloaddition reaction. The method used in this experimentation was based on the fundamentals of Click Chemistry. Since, reactions designed according to the concepts of Click Chemistry produced inoffensive byproducts and high yields, it was hypothesized that this reaction would produce a new methodology in how to synthesize cyclooctyne reacted complexes and produce an unknown organic complex. The primary goal in this research was to form an unknown* complex
9, 10-Dihydroanthracene Lab Report
673 Words | 3 PagesThe objective of the experiment completed was to form the product 9,10-dihydroanthracene-9,10-α,β-succinic anhydride from anthracene and maleic anhydride. The reaction that took place is named a Diels-Alder reaction, defined as an addition reaction in which a diene unites with a double or triple bond of an unsaturated compound to form a 6-membered-ring. The following reactions below depict the ways in which dienes and dienophiles join to form products. Anthracene functioned as a diene and maleic anhydride functioned as the dienophile. Xylene was used as a solvent that provided a quicker way of reaction between the two starting materials.
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