Clopidogrel Drug Analysis
Clopidogrel is a pro-drug, upon being orally administered in its inactive form, is first absorbed by the intestines then transferred to the liver where activation of the drug occurs by CYP450 [3,4]. However, only 15% is catalyzed by the cytochrome enzymes, whereas the majority of the Clopidogrel is hydrolyzed by esterases to its inactive carboxylic acid derivative [4,5]. Hepatic and Polymorphic CYP450 enzymes catalyze the oxidation of thiophene ring in Clopidogrel to its intermediate metabolite: 2-oxoclopidogrel [5]. 2-oxoclopidogrel is then further oxidized, resulting in opening of the thiophene ring to form a carboxyl and a thiol group [5]. The thiol group will irreversibly bind via a disulfide bone to a free cysteine on P2YR12 ADP receptor
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Cystic Fibrosis: A Genetic Disease
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Atrazine Research Paper
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Celebrex Research Paper
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The Importance Of Therapeutic Drug Monitoring
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