Clubfoot Essay

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The deformation known as clubfoot is a standout amongst the most widely recognized birth imperfections including the musculoskeletal framework. It presents intrinsic dysplasia of every single musculoskeletal tissue distal to the knee. It is a deformity in which the foot is twisted so that the sole cannot be placed flat on the ground. Understanding the microscopic structure of diseased tissues that characterize clubfoot are very important areas of research. The major component of the ligament, muscle, tendon, bone and joint cartilage involved in clubfoot is collagen. Prolidase enzyme activity is required for collagen biosynthesis. Collagen is key for the support of connective tissue.
This study called attention to the part of serum prolidase action and its relationship with oxidative-antioxidant status in patients with clubfoot. Collection of blood samples, oxidative stress index, and statistical analysis along with the measurements of serum prolidase activity, total free sulfhydryl groups, total antioxidant capacity and
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It additionally demonstrated that total free sulfhydryl levels and total antioxidant capacity were lower. It can be presumed that elevated total oxidant status and oxidative stress index levels result in oxidative damage and higher prolidase action results in a rise of collagen production. Over the course of the ailment with clinical changes, serum prolidase activity and oxidative status variables diminished and antioxidant status variables were elevated. As a result, serum prolidase action and oxidative antioxidant status variables might be adjunctive apparatuses for the subsequent treatment of clubfoot. A relationship between serum prolidase applications, disease activity and bone metabolism has been proved for clubfoot as well as for other musculoskeletal

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