Garcinia Pedunculata Roxb Essay

INTRODUCTION:

Garcinia pedunculata Roxb., Fam. Clusiaceae is a tree bearing yellow coloured fruits common in dense forests of north east India and Andaman Nicobar Islands. The dried rind of the mature but not fully ripen fruits has high medicinal value and used in diet of tribes at Assam and North eastern states of India (Kagyung et al., 2010). It is used in various ailments such as fever, cough, bronchitis, asthma, rheumatoid arthritis, obesity and used as a cardiotonic drug (Jayaprakasha et al., 2006). The phytochemical analysis of fruit rinds (GPFR) has shown phytochemicals such as pedunculol, garcinol, cambogin (Sahu et al., 1989) and (-)-hydroxyl citric acid (Jayaprakasha et al., 2003). Hexane and chloroform extracts of GPFR showed antioxidant activity, free radical scavenging activity and strong antimutagenicity hexane extract being more active than chloroform3. The chloroform and hexane extract of GPFR showed MIC on growth of Aspergillus flavus at 3000 and 4000 ppm respectively (Jayaprakasha et al., 2006). GPFR is reported to have antibacterial (Negi et al., 2008), hepatoprotective, anti-inflammatory and cardio protective activities (Ravi et al., 2014a, 2014b, 2016).

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The tissue homogenate (0.2ml) was added to the test tube containing 0.2ml of EDTA, sodium azide, reduced glutathione, hydrogen peroxide and added 0.4ml of buffer mixed well and incubated at 370c for 10 min. The reaction was arrested by adding 0.5ml of TCA and centrifuged. The supernatant (0.5ml) was pipette into test tube containing 4ml of disodium phosphate and 0.5ml of DTNB. The colour developed was read at 420nm immediately and standard also treated in the similar manner. The level of glutathione peroxidase was expressed as µmoles of glutathione utilized /mg protein/min at 370c (Rotruck et al.,