887 Words4 Pages

3.0 Aim and Objectives
3.1 Aim
To develop and evaluate the physical compact properties of co-processed sago starch granules as direct compression excipients.
Objectives To prepare co-processed sago starch granules To prepare compacts of co-processed sago starch granules at different compression forces To measure the thickness and diameter of compacts sago starch To evaluate the elastic recoveries of compacts sago starch To evaluate the hardness of compacts sago starch To evaluate the friability of compacts sago starch To evaluate the disintegration time of compacts sago starch To evaluate the deformation properties of compacts sago starch
Methodology
Preparation of co-processed sago starch granules The co-processed sago starch granules were prepared by mixing*…show more content…*

For uncoated compacts, it should disintegrate and no granules should be left in the disintegration apparatus more than 30 minutes (The United States of Pharmacopeia Convention, 2007). Evaluation of deformation properties of compacts Hackels and Kawakita equations (Equation 3 and 5) were used to assess the deformation properties of compacts (Zhang, Law, & Chakrabarti, 2003). Heckel’s equation: kP + A= ln〖1/(1-DA)〗…………………… (Equation 3) Where P is the compression pressure of compacts and DA is the relative density (Equation 4). DA = ρα/ρτ……………………………………………..……… (Equation 4) Where ρA is the apparent density compacts and ρT is the true density of a powder. The Heckle plots of ln〖1/(1-DA)〗 against P were established. The slope of the plot represents the k value, which reflects the deformation of the particle under compression. While the intercept of the plot represents the A value, which reflects the particle rearrangement and die filling before deformation. Kawakita’s equation: P/C=(p/a+1/ab) ………………… (Equation

For uncoated compacts, it should disintegrate and no granules should be left in the disintegration apparatus more than 30 minutes (The United States of Pharmacopeia Convention, 2007). Evaluation of deformation properties of compacts Hackels and Kawakita equations (Equation 3 and 5) were used to assess the deformation properties of compacts (Zhang, Law, & Chakrabarti, 2003). Heckel’s equation: kP + A= ln〖1/(1-DA)〗…………………… (Equation 3) Where P is the compression pressure of compacts and DA is the relative density (Equation 4). DA = ρα/ρτ……………………………………………..……… (Equation 4) Where ρA is the apparent density compacts and ρT is the true density of a powder. The Heckle plots of ln〖1/(1-DA)〗 against P were established. The slope of the plot represents the k value, which reflects the deformation of the particle under compression. While the intercept of the plot represents the A value, which reflects the particle rearrangement and die filling before deformation. Kawakita’s equation: P/C=(p/a+1/ab) ………………… (Equation

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