Coagulation System Essay

Coagulation system is a process to prevent blood loss from the body. Hemostasis process occurred in three phases, vascular platelet phase, activation of the coagulation cascade and the activation of a control mechanism. Mostly, the system is triggered by a damaged blood vessel. After vascular injury, rapid vasoconstriction will serve to reduce blood flow. At the same time, von Willebrand factor (vWf) will act as a bridge between endothelial collagen and platelet surface receptor glycoprotein Ib (GPIb) which will promote platelet adhesion (Green, 2006). After platelet adhesion, degranulation from the platelet granules will release calcium. Calcium will bind to the phospholipid which provides a surface for the assembly of the coagulation factor.

Rhizoma Atractylodis Lanceae will collect in spring and autumn by removal of aerial parts and fibrous roots, after drying under the sun. Rhizoma Atractylodis Lanceae is used in the formula rather than single to against rheumatic disease, edema, digestive disorder and common cold (Wagner, 2011). Furthermore, Rhizoma of Atractylodis Lanceae has an anti-anoxic effect, anti-ulcer effect and anti-tumor effect. Rhizoma Atractylodis Lanceae can increase bile secretion and gastrointestinal motility activity (Yamahara et al., 1990). The taste of the Rhizoma Atractylodis Lanceae is pungent and bitter, the spleen and stomach channel will be entered. The active component of the Rhizoma of Atractylodis Lanceae is an essential oil (3.5-7%), which is included atractylon, atractylodin, elemol, hinesol. Atractylon is the active compounds in anti-inflammatory effect (Yamada and Saiki, 2005). Some research stated that Rhizoma of Atractylodis Lanceae components shown inhibitory effect on platelet aggregation. Since Rhizoma of Atractylodis Lanceae may suppress the signal pathway of the release of thromboxane A2 (Nasu et al., 2009) Therefore, Rhizoma of Atractylodis Lanceae may have an anti-coagulation effect on human