Combination Therapy Research Paper

Combination therapy refers to the use multiple medications to fight a particular condition like type II diabetes. In this article, the focus is on combination therapy used to manage type II diabetes. The practice isn’t new and has been effective in many patients. Nowadays, there are many type II diabetes medications which work in different ways; hence combination therapy can be very effective. The medical care practitioner will pick the best drugs which will be effective in controlling blood glucose levels in a particular patient such as Junamet.

What is Junamet?

It is a prescription drug available in the form of a tablet and given to patients who have been on a maximum dose of Metformin but their blood glucose hasn’t been effectively controlled.

To start with, it minimizes the quantity of glucose produced by cells in the liver. Additionally, it makes the muscle cells sensitive to insulin and finally it slows the absorption of glucose from the intestines into the blood after food consumption.

• Januvia (the active ingredient is sitagliptin)- it belongs to a class of medication by the name DPP-4 inhibitor. It lowers blood glucose levels by hindering breakdown of two incretin hormones by the name glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). The hormones are naturally released after eating food. They trigger the pancreas to produce more insulin to respond to elevated blood sugar levels. Furthermore, they lower the release of glucagon (it’s a hormone that stimulates glucose production by the liver) and affects the brain which makes one feel full, hence reducing food consumption. Through these actions, blood glucose level is regulated, but the patient might be faced with Junamet side effects.

Junamet drug controls sugar levels directly after and between meals. It comes in different strengths such as:

• 50mg / 500 mg (50 mg Januvia and 500 mg Metformin)

• 50 mg/ 850 mg

• 50 mg/ 1000