Polymeric Membranes Lab Report

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Abstract New copolymeric membranes was offered for the efficient delivery of antibiotic drug using the synthesized chitosan–copoly(semicarbazide–formaldehyde–phenylhydrazine) blend membranes. The membranes were prepared by solution casting technique and characterized by elemental, spectral and scanning electron microscopy to establish the chemical structure and morphology. Scanning electron microscopy clearly reveals that the increased porosity in the polymeric network enables rapid swelling; leads to faster diffusion which facilitates effective drug release. The composition of chitosan content also governs the swelling behavior i.e. increased chitosan content showed excellent swelling behavior leads to profound drug delivery. The drug delivery results clearly indicates that the chitosan and its blend membranes have effectively released the antibiotic drug in a short time and proved to be a promising candidate for the drug delivery. The kinetic study of the drug release profile clearly establishes that the drug release is very well fit with the Higuchi model and also follows swelling and…show more content…
The reaction mixture was then cooled and poured into crushed ice with constant stirring and left overnight. A dark red coloured copolymer was obtained and washed with warm water, methanol and acetone followed by filtration to remove unreacted monomers and impurities. Finally, the copolymer was dried in an air oven at 75 °C for 24 h. The yield of the copolymer was found to be 85%. The copolymer was found to be soluble in solvents like dimethylsulphoxide, dimethylformamide and tetrahydrofuran and partially soluble in mineral acids. The mechanism of the synthesis of copolymer (SFP) is shown in Scheme

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