Creams In Water In Oil Cream

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Creams are semisolid dosage forms containing one or more drug substances dissolved or dispersed in a suitable base. This term has traditionally been applied to semisolids that possess a relatively fluid consistency formulated as either water-in-oil (e.g., Cold Cream) or oil-in-water
(e.g., Fluocinolone Acetonide Cream) emulsions. However, more recently the term has been restricted to products consisting of oil-in-water emulsions or aqueous microcrystalline dispersions of long-chain fatty acids or alcohols that are water washable and more cosmetically and aesthetically acceptable. Creams can be used for administering drugs via the vaginal route (e.g., Triple Sulfa Vaginal Cream).
Bases
There are two types or bases of creams: oil-in-water (O/W) …show more content…

Oil-in-water creams are more comfortable and cosmetically acceptable as they are less greasy and more easily washed off using water. water-in-oil (W/O) creams which are composed of small droplets of water dispersed in a continuous oily phase. Water-in-oil creams are more difficult to handle but many drugs which are incorporated into creams are hydrophobic and will be released more readily from a water-in-oil cream than an oil-in-water cream. Water-in-oil creams are also more moisturising as they provide an oily barrier which reduces water loss from the stratum corneum, the outermost layer of the …show more content…

The solid excipients are melted at the time of preparation. Emulsifying agents include nonionic surfactants, detergents, and soaps. Soaps are usually formed from a fatty acid in the oil phase hydrolyzed by a base dissolved in the aqueous phase in situ during the preparation of creams. Preparation usually involves separating the formula components into two portions: lipid and aqueous. The lipid portion contains all water-insoluble components and the aqueous portion the water-soluble components. Both phases are heated to a temperature above the melting point of the highest melting component. The phases then are mixed and the mixture is stirred until

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