In many cases the association process is a part of biological function as in blood clotting or the formation of muscle fibers. Aggregation of proteins also leads to perturbation of the biological function with sometimes serious physiological consequences as in the formation of cataracts in the lens of the eye or amyloid fibrils associated with Alzheimer’ and other neurological diseases. From a colloid chemistry perspective, protein self-association is a special case of the general problem of colloid stability. There are two important aspects of the protein systems in this respect: first in contrast to colloids in general the system can be obtained in pure form and then represent a true single component. Second the protein has a complex molecular structure and one should expect protein- protein interactions to be highly directional.
Abstract: Zellweger syndrome is an autosomal and recessive disease. It is part of one a 4 disease of disorders known as peroxisomal biogenesis disorders. It is caused by absence of peroxisomes, which remove the body of toxic substances in the liver, brain, and kidneys. The most common features the zellweger syndrome patients include swell liver, high levels of copper and iron in the blood, and vision disturbances. This disorder results from the inheritance by 2 mutations genes for one of the receptors (PXR1) needed to import proteins into the peroxisome.
ACUTE MYELOID LEUKEMIA If a doctor insists that a patient has leukaemia, more drafted measures should be taken into consideration. Measures which include the use of samples taken from the blood because it is not often the case where signs and symptoms might suggest that the patient have leukaemia, other measures include the results of the physical exam made by the doctor and the samples of cells from the blood, the bone marrow and the spinal fluid. DIAGNOSIS Before a patient can be diagnosed with AML, a few tests should be done especially those of the bone marrow and spinal fluid. SAMPLES (This is the beginning of the diagnosis) Blood samples are taken from the vein of the arm by an injection. Bone marrow samples are taken in two different
Normally, microsporidia do not cause disease in healthy people but in people with immune system deficiency. It is specially very common in insects and fish. What harm can it cause? It can cause kidney disease, infection of the eyes and sinuses, and cause chronic diarrhea. Microsporidia causes a disease called Microsporidiosis.
But a small hole in the skull is first made, known as blur hole in order to pass the needle through it. Risks Associated with Screening: Although the tests are the only ways to detect brain tumors, sometimes these tests may pose some risks. For example, during a stereotactic biopsy there are chances of bleeding which can cause mild problems like headache to serious issues like stroke, coma and the worst,
But what causes this disease? The production of the thick and sticky mucus occurs because of a mutations in a gene on chromosome 7. Cystic Fibrosis happens because of mutations in the gene that makes a protein called CFTR or “Cystic Fibrosis Transmembrane Regulator”. Cystic Fibrosis patients either produce uncommon CFTR protein or no CFTR protein at all. This mutation causes your body to make a thick and sticky mucus, instead of the thin and watery mucus that your body needs to function efficiently and healthy.
The pathogenesis of VHL syndrome involves mutation in VHL gene located in the short arm of chromosome 3 which encodes a messenger RNA.1 This eventually leads to abnormalities in protein complexes involved in regulation of senescence, oxygen-sensing pathway, microtubule stability and orientation, cilia formation, assembly of collagen (type IV) and fibronectin in extracellular matrix and in tumor suppression. Although not described previously, the pathology can theoretically involve airway mucosa as it also contains epithelial cells, cilia, type IV collagen and
These bumps can appear anywhere on the body, though it is unusual to find it on the soles of the feet or the hands. The virus is located in the top layer of the skin, the epidermis, and doesn’t circulate throughout the body. Many people mistake the molluscum contagiosum virus for the common chicken pox virus, but the difference can be found in the characteristics of the lesions: chicken pox spots are water-filled blisters while molluscum are more dome-shaped and pearly. The virus is most common in young children (1-10 years old) and adults. People with weakened immune systems have an especially hard time with the molluscum virus, often suffering a more severe case of the virus while having a more difficult time treating it.
Platelets help control bleeding in an interesting process call hemostasis 3. In this process when an injury occurs to a blood vessel, causing bleeding the platelets start to stick to the injured blood vessel and release chemicals to attract other platelets. 4. Then as more platelets start sticking together they soon form a temporary clot V. The blood vessels guide blood and help the blood travels through our body. A.
Abstract: Ocular lymphomas are rare malignancies that display a myriad of clinical manifestations; therefore the diagnosis can be a challenging task. Almost all intraocular lymphomas are B cell non-Hodgkin’s lymphomas. Although the orbit is an extranodal site where lymphocytes are not found under normal conditions, lymphoid tumors are the third most common cause of proptosis in the adults. Ocular lymphomas are most challenging cases seen by ophthalmologists and are more serious eye conditions, leading possibly to blindness and death. We describe a series of 4 cases which presented as ocular adnexal masses and a view on clinicopathological details.
This causes accumulated lipids to be caught in the endosomes. While some of these genetic diseases like Tay-Sachs only result in death, there are new theories that cell therapy could help in some like Gaucher disease. The glycogen storage diseases are Glycogen Storage disease, types I and II. Glycogen Storage Diseases can be found by taking a blood test. These involve enzymatic deficiencies.