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Crospovidone Analysis

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6. EXCIPIENT PROFILE
Polyplasdone XL :
Synonyms: Crospovidone, Cross-linked povidone, PVPP, polyvinylpolypyrrolidone.
Functional Category: Tablet disintegrant.
Applications: It is a water insoluble tablet disintegrant used at 2-5 % concentration in tablets prepared by direct compression or wet & dry granulation method.
Description: White to creamy-white, finely divided, free- flowing, practically tasteless, odorless or nearly odorless, hygroscopic powder.
Solubility: Practically insoluble in water and most organic solvents.
Stability: Crospovidone is stable.
Storage conditions: Since it is hygroscopic it should be stored in an airtight container in a cool, dry, place.
Incompatibilities: When exposed to a high water level it may form molecular …show more content…

Deliberate abuse of formulations containing cellulose, either by inhalation or by injection, has resulted in the formation of cellulose granulomas.

Magnesium Stearate:
Synonyms: Dibasic magnesium stearate, magnesium distearate, Magnesia, stearas, Magnesium octadecanoate, Octadecanoic acid, magnesium salt, Stearic acid, magnesium salt.
Structural formula : [CH3 (CH2)16COO] 2Mg
Chemical name : Octa decanoic acid magnesium salt [557-04-0].
Empirical formula : C36H70MgO
Molecular weight : 591.24 daltons.
Description: Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odour of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin.
Functional category: Tablet and capsule lubricant.

Physicochemical properties:
Solubility: Practically insoluble in ethanol (95%), slightly soluble in water and ether.
Melting point : 117-150°C (commercial samples).
Flow ability : Poorly flowing, cohesive

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