Precision and accuracy of the analysis are pretty much important in the optimization of these process. It is widely used in bioanalytical measurements, as well as concentrating trace amounts of analyte, rather than to straightforward quality control of active pharmaceuticals ingredients. Quality control of active pharmaceutical ingredients in a particular formulation normally will involve a simple extraction procedure. If there is any interference problem rising from the excipients after extraction, we can use chromatography to resolve the active pharmaceutical ingredient from interferants allow quantification. However, low dosage formulations and also advanced drug delivery formulations most probably will need a more detailed handling of
Analysis was performed at 25 ± 2oC. The NLC dispersion was diluted with double distilled water. Few drops of the dispersion were placed on the cover slip and allowed to dry in rotator drier to form a hard film. After formation, the images were captured (Fig. 5.4).
2 drops of phenolphthalein is added to the solution by using dropper. The colour of the solution change to light red. 4. Burette is filled with sulphuric acid to titrate the solution with drop by drop while the conical flask is shaken slowly until the light red colour disappear. 5.
The end result of the clotting pathway is the production of thrombin for the conversion of fibrinogen to fibrin. Fibrinogen is a dimer soluble in plasma. Exposure of fibrinogen to thrombin results in rapid proteolysis of fibrinogen and the release of fibrin peptide A. The loss of small peptide A is not sufficient to render the resulting fibrin molecule insoluble, a process that is required for clot formation, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. A second peptide, fibrin peptide B, is then cleaved by thrombin, and the fibrin monomers formed by this second proteolytic cleavage polymerize spontaneously to form an insoluble gel.
carboxymethylcellulose sodium and xanthan gum. This might be due to amorphous state of the drug in solid dispersions, wettability improvement, reduction in particle size and increase in the effective surface area over which the drug distribution increases. The results of study demonstrated the suitability of selected polymer xanthan gum and NaCMC in the preparation of solid dispersions as effective carrier for increasing solubility. As these swellable polymers are regularly used in conventional solid dose preparations and herbal polymer is readily available at low cost, this ensures about the availability, feasibility in use and cost effectiveness of the formulations. Overall, this research work presents a very simple but effective technique for dissolution enhancement using very common polymers.
ABSTRACT: Pantoprazole sodium is an antiulcer drug. This compound inhibits gastric acid formation and thereby it is very efficient for the treatment of gastric and duodenum ulcers. But pantoprazole sodium is acid labile drug that will degrade in acidic environment of stomach resulting in therapeutic inefficacy. Hence it is necessary to bypass the acidic pH of the stomach which can be achieved by formulating delayed release dosage forms (single unit or multiple units) by using different enteric polymers The present study was an attempt to formulate and evaluate enteric coated tablets for pantoprazole sodium sesquihydrate. Different core tablets were prepared using different superdisintegrants (Sodium starch glycolate, croscarmellose sodium,
Each component that made up the oral suspension has its own role or function. Posaconazole is the active ingredient in the oral suspension which will interact with its target whereas polysorbate 80 acts as surfactant and non-ionic wetting agent which lowers the surface tension of the liquid thus allowing the drug particle to be evenly dispersed. (4) Simeticone is used as antifoaming agent which reduce the formation of foams during reconstitution and manufacturing process. Simethicone lowers the surface tension of foams and form bigger foams thus will makes the trapped air in the foams to escape easily. (PE) Sodium benzoate has the antimicrobial properties and is used in the oral formulation as preservative.
In general RPLC, gradient elution is usually used for the analysis of a mixture of compounds with wide range of polarities. A good alternative to this is MLC using a single mobile phase affording appropriate retention times of multi component pharmaceutical samples, such as pharmaceutical formulations (capsules, creams, drops, enemas, oily injections, ointments, pills, solutions, sprays, suspensions, syrups and tablets) and also biological samples containing drugs of diverse
Besides that, the Cobb test is carried out to identify the rate of water absorption of the both sides of sample paper. The experiment is based on starch extraction with hydrochloric acid, HCl and selective retention of the starch-iodine complex on the filtration flask with Whatman No.40 filter paper placed inside. The starch on the filter
Chapter3. AIMS AND OBJCETIVE OF THE STUDY The Project is aimed at development of mucoadhesive drug delivery system of antihypertensive drugs diltiazem hydrochloride and nifedipine respectively. These drugs are selected on the fact that both drugs are having short half life, both undergoes hepatic metabolism at the same time both gets absorbed from gastrointestinal tract rapidly, though diltiazem hydrochloride is hydrophilic and nifedipine is hydrophilic. Marketed formulations are available in the form of sustained release tablets capsules. So alternative drug delivery system can serve the purpose of delivering the drug at a particular site and which can bring about slow release and improved bioavailability may be achieved is needed .