Cyclodextrin Lab Report

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1. INTRODUCTION
1.1. CYCLODEXTRIN1, 2, 3:- For drugs to be pharmacologically active, they essential have assured degree of water solubility, and also maximum of them should be lipophilic in instruction to be permeable to the biological membranes through passive diffusion. The water solubility of drug is characterized by its potency and its type of formulation. The hydrophilic property will prevent the dissolved drug molecule to separate from the hydrous exterior into a lipophilic bio membrane and then permeate the membrane. High-throughput screening techniques involved in the drug development have resulted in an increased number of lipophilic water-insoluble drugs whose clinical advantages are affected by their insolubility in water. The effect
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Complexation techniques(1,13,12)
Different methods can be used to transport out the complexation of the cyclodextrin with drug. approximately of which are described lower:
1.4.1. Physical blending/milling/co-grinding: Mechanical energy is used to mixture, mill or co-grind the drug and the cyclodextrin.
1.4.2. Kneading Technique: In this technique Cyclodextrin is initially taken in mortar then drug is gradually further into it and using small percentage of water it is triturated using pestle to get a paste like uniformity. The over head paste is kneaded for enough time then this mixture is dried and is passed through appropriate sieve.
1.4.3. Co-precipitation technique: The Cyclodextrin and the drug are additional to water or alcohol and a saturated solution is shaped at 40-600C and after that it is cooled to precipitate the complex and it is clarified or centrifuged.
1.4.4. Freeze drying technique: In this technique, water and co-solvent blend is used to dissolve drug and Cyclodextrin, and by freeze drying the solution complexes can be isolated.
1.4.5. Spray drying: Using appropriate solvent a monophasic solution of drug and CD is equipped then it is stirred to achieve equilibrium and then solvent is impassive by spray
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Cyclodextrin in drug delivery system
This division mostly deals with the presentation of cyclodextrin in oral, rectal, sublingual, ocular, nasal, pulmonary, and in dermal delivery system.

1.6.1. Oral drug delivery
When oral administration, the drug release time summary can be separated into two kinds, rate measured and time measured categories. Rate measured type can be additional separated into instant release, sustained release, and altered release types.
1.6.2. Instant release
Dissolution rate of the drugs commonly selects its rate and amount of bioavailability. Due to the improved solubility and wet capability of the drugs concluded the development of inclusion complexes, Hydrophilic cyclodextrins aids in cumulative the oral bioavailability of steroids, non- steroidal anti- inflammatory drugs, antiepileptic, anti -diabetics, vasodilators.
1.6.3. Sustained release
Alkylated and acylated products of Cyclodextrins which are hydrophobic in nature are used as gentle release movers for water soluble drugs.
1.7. Effect of cyclodextrin on the properties of drug in preparation
1.7.1. Effect on drug solubility and dissolution

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