Cyclophosphamide Case Study

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C.) The nurse would monitor for therapeutic effect of cyclophosphamide(Cytoxan) by continuing monitoring the blood pressure, respiratory rate, and temperature, ensuring they are within the range that the doctor set. You would also need to monitor complete blood count (CBC) and should be maintained at 2500– 4000/mm^3. Urinary output is important aspect when making sure the drug is in therapeutic range. You would want to monitor the urinary output to make sure it is in the range of 3000 ml/day so they are not developing the risk of hemorrhagic cystitis. Make sure to assess the cardiac and respiratory status for dyspnea, crackles, cough, weight gain, and edema. Pulmonary toxicity happens when prolonged therapy of drug. Another important thing to look for is bone marrow depression but monitoring for bleeding of gums, bruising, petechia, guaiac stool, urine, and emesis.…show more content…
The article “The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients” shows that there is a significant difference between race. The purpose of this articles is to determine if the aprepitat influences pharmacokinetics of cyclophosphane. African Americans have significantly higher 2-dechloroethylcyclophosphamide concentrations, compared to Caucasians. Aprepitat is nausea and vomiting caused by chemotherapy. In conclusion, the race and aprepitant influences the use of cyclophosphamide. African Americans had an altered pharmacokinetics compared to
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