Cystic Fibrosis Transmembrane Regulator (CRTF)
Cystic Fibrosis is an inherited disorder involving fluid secretion by the exocrine glands in the epithelial lining of the respiratory, gastrointestinal, and reproductive tracts (Porth, 2011, p.584). The cystic fibrosis transmembrane regulator (CRTF) gene helps in the regulation of chloride through the epithelial membrane of the cells. A mutation in the CRTF gene causes impaired transport of chloride which increases sodium absorption and water into the blood. Once water moves into the blood it lowers the amount of water of the mucociliary blanket of the respiratory epithelium. Thus, the mucociliary function to not work and secretions (or thick mucus) to build up and block up airways (Porth, 2011, p.585). Those who are affected by Cystic Fibrosis …show more content…
One might experience respiratory signs and symptoms caused by the blocking of air passages and lungs with thick mucus such as repeated lung infections (pneumonia or bronchitis), wheezing or shortness of breath. One might also experience digestive signs and symptoms such as those mentioned in the CRTF.INFO.’s website informational article, gastrointestinal tract problems such as congenital Meconium ileus and distal intestinal obstruction syndrome, are caused by the decrease in chlorine and water secretion into the gut. These problems can play a factor in Cystic Fibrosis patient inability to absorb the vital nutrients they need. Also included is the buildup of digestive enzymes and digestion of its own tissues in the pancreas created by the thickening of exocrine secretions that block the pancreatic ducts intestinal blockage which results in bowel movement problems like diarrhea, gas, and abdominal pain. Not only can Cystic Fibrosis affect the pancreas and gastrointestinal tract but also the liver’s secretions. In small cases, the liver’s bile can become thick and cause build up and blockage in the hepatic ducts which can result in liver diseases and even cirrhosis. Some other common symptoms include above normal amount of salt in the person’s sweat and male
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948 Words | 4 PagesDiscovered in 1989, Cystic Fibrosis is the most common, fatal genetic disease in the United States. Statistics show that 30,000 people in the US have been named with this disease. (Genome) Cystic Fibrosis is a disease caused when the CFTR (Cystic Fibrosis Transmembrane Regulator) is defective and the cells do not release the right amount of chloride. This causes for the body to produce thick, sticky mucus that clogs up the lungs, leads to infection, blocks the pancreas, which stops the digestive enzymes from reaching the intestine. Symptoms require; salty tasting skin, wheezing, shortness of breath, persistent coughing, poor growth or weight gain, frequent/bulky stool, and male infertility.
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