INTRODUCTION Gentamicin, which is a broad spectrum aminoglycoside antibiotic (Fig. 1), belongs to the class of medicinal compounds capable of inhibiting the growth of Gram-positive and Gram-negative bacteria . Gentamicin is one of the most effective drugs used in the treatment of serious suppurative and septic processes, especially those that are caused by Gram-negative microorganisms. The advantages of gentamicin over other aminoglycosides (kanamycin, neomycin) are its activity towards Pseudomonas aeruginosa and microorganisms of the Serratia–Klebsiella–Enterobacter group, a faster bactericidal effect, and the rare development of gentamicin resistant strains. Several methods used for determination of GT including colorimetric [2,3], amperometric enzyme-immunosensors , flow injection chemiluminescence , spectrofluorometry [6,7], capillary electrophoresis with UV detection , liquid chromatography (LC) [9–14] and high performance liquid chromatography (HPLC) [15–23]. Kinetic methods have many advantages over other spectrophotometric methods due to their high selectivity and elimination of
1.Introduction: Ox diazole, a heterocycles nucleus has attracted a wide attention of the chemist in search for new therapeutic molecules. Five member heterocycles compounds show various type of biological activities among than 2,5-distributed 1,3,4-ox diazole are associated with diverse biological activities . Various biological activities like antimicrobial, anti-tubercular, anti-inflammatory, Anticonvulsant , Hypnotic , Anesthetic activity . 1,3,4-ox diazole showed antibacterial properties similar to those of well known sulfonamide drugs. The ox diazole nucleus with N=C-S linkage exhibits a large number of pharmacological activities .
1. Introduction of exogenous DNA into animal cell lines, plant protoplast, yeast protoplast and bacterial protoplast. 2. Electroporation can be used to increase efficiency of transformation or transfection of bacterial cells. 3.
The reactions involving such kind of antigen and antibody interaction are known as agglutination reactions. This type of reaction occurs at the surface of erythrocytes, bacterial cells or animal cells at which the antigens are present .The results of these reactions are clearly observable since they form large sedimented particles in form of visible clumps. Formation of clumps is due to antigen and antibody complex formation. The ease of its performance and identifiable results make it viable for large clinical importance. Its most important clinical application involves the detection of bacterial infection.
The team of experts was trying to synthesize a cure for skin cancer through exposure to ultraviolet light. The trials started in the early nineties, by the scientists trying to create a synthetic version of the alpha-melanocyte body stimulating hormones. The venture was a success with the discovery that they can be able to stimulate more melanin with Melanotan 2. There was the added benefit of the peptide being able to also increase energy and libido.
The MRI brain of the patient showed hyper-intensities in bilateral dentate nuclei on T2 FLAIR images, suggestive of Metabolic Encephalopathy. On stopping metronidazole, patient showed recovery in one week. BACKGROUND Metronidazole is a very commonly used antibiotic for bacterial and protozoal infections. The drug causes a variety of neurological side effects-ranging from mild giddiness to frank Encephalopathy. Metronidazole is an imidazole antibiotic that is used for the treatment of protozoal, bacterial and various parasitic infections.
Studies show that the Fennel seed extract can inhibit growth of tumor. It’s probably because of its flavonoid and alkaloid concentration. These chemicals present in fennel can fight the free radicals roaming in our blood, which are supposedly responsible cancer. 5. Cure for constipation Fennel seeds contain large amount of fibre and can hence act as excellent laxative.
Abstract The DNA analysis becomes a cornerstone in contemporary forensic sciences. DNA sequencing technologies are powerful tools that enrich molecular sciences in the past based on Sanger sequencing and continue to glowing these sciences based on Next Generation Sequencing (NGS) technologies. NGS has impressive potential to flourish and increase the molecular applications in forensic sciences by jumping over the pitfalls of the conventional method of sequencing. The main advantages of NGS compared to conventional method are their higher throughput (parallel sequencing which will help in reducing DNA backlogs), lower cost and short run time with high resolution of genetic data. These advantages will help in solving several challenges that
After treatment with L-thyroxine, the pressure marker is reduced to a considerable degree. MDA can also be used as a useful biomarker to measure and monitor oxidative stress. The role of antichrist in the form of selenium is incomplete (5). In our research we find antioxidant status in hypothyroidism Material and
The mechanism of action is as follows: Initially, given that it is a pro drug, it should be activated by the mycobacterium catalase peroxidase enzyme, which is regulated by the kat G gene. Then it enters tuberculosis bacilli by active diffusion. After activation by kat G, isoniazid converted to a wide range of radicals or reactive species and isotonic acids which can include both inactive oxygen species and radical species organic radicals. These radicals and species role is to attack multiple targets include: mycolic acid Synthesis, damage to DNA, lipid peroxidation and the nicotinamide adenine dinucleotide (NAD) metabolism in the cell.
One for example, is Pure and Applied science. Applied science is demonstrated when Tsien uses fluorescent protein to analyze changes in cells. Using this method, he was able to create a way to identify different types of cells; even recognize cancerous ones. His scientific discovery exemplifies applied science due to the use of knowledge to create a system or technology to differentiate cells and their properties. Pure science is indicated when the author mentions Sir George Gabriel and his discoveries.
Methicillin Resistant Staphylococcus Aureus Methicillin Resistant Staphylococcus Aureus (MRSA) is a bacteria resistant to all antibiotics containing penicillin. MRSA otherwise known as a superbug has been produced through the process of natural selection inside hospitals, which provide the perfect environment for this bacteria to thrive in. Bacteria like MRSA are hard to treat as there are fewer antibiotics to treat it therefore increasing its deadliness. The antimicrobial resistance in MRSA is genetically based, meaning that it can spread its immunity amongst other bacteria by horizontal gene transfer. MRSA is a bacteria that can withstand antibiotics containing penicillins.