Capsule is a solid dosage form which contain active pharmaceutical ingredient encompass with different types of shells and sizes. They are made of different composition but mostly it is made with Gelatin extracted from animal bones and skin (choudhary, 2008-2017). There are two main types of Capsules 1- Hard Gelatin Capsule a. Hard gelatin capsules normally come in two pieces body and cap and normally they are cylindrical shape or bullet shape. b. API 's are powders, granules, tablets and pallets coated drugs which are encapsulated in hard shell. c. Gelatin is hard, but they are water soluble and biodegradable shells. d. Hard capsules are normally sealed after they been filled properly ensuring the API 's does not comes out when handle. e. Hard capsules come in eight different sizes. 2- Soft Gelatin Capsule: a. …show more content…
To achieve good results, we need to introduce high sheer blender typically performed v- blenders with high speed intensifier bar which keep powder dry, maintain their shape, size and reduce lumping together. Particle with isometric shape and they are round are best for hard capsule while anisometric shape is having problem with the flowability and they have higher tendency to adhere with walls and they take more surface area. b- Particle solubility: Solubility depends on lot of factor like shape and size long with their capacity to dissolve and disintegrates in solvents. Fine particle of powders like small size, round shape with anhydrates capability of particle will dissolves and disintegrates quicker than that of crystalline with anisometric shape which have slower dissolving and disintegrating properties. c-
C is for Cassoday Cassoday is my twenty one year old sister. Cassoday was named after a town by Newton, it is spelled the same and pronounced the same. Cassoday is my oldest sister and she is one out of five including me. Today is December third, it is her birthday and in her birthday I send her an email saying happy birthday all my friends say the same thing, hope your day is a great one.
This beaker was heated in a hot water bath until the solid dissolved in the solution and was cooled in an ice water bath for 15 minutes. Crystals were gathered via vacuum filtration and the stir bar was removed. The mass of the final product was 0.52g and 57.33 % recovery, with a melting point of 166.5-170.6
This may not seem like much of a problem, but consider this: a
Overview According to New Jersey Department of Health and Senior Services, On April 21, 1995, an explosion and fire occurred at a company named Napp Technologies, Inc. that caused several fatalities and major damage to the building and equipment (www.nj.gov.) The company was a facility that mixed chemicals to create other products, mainly pharmaceuticals, but on occasion would mix chemicals for other companies that did not have the capabilities. The explosion occurred in a chemical mixing tank containing aluminum powder, sodium hydrosulfite, potassium carbonate and benzaldehyde (www.nj.gov). The fire burned for several hours and involved federal, state and local emergency response personnel to finally extinguish.
1. Amlodipine: • US Brand Names: Norvsac • Generic Names: Amlodipine • Dose/Route/Frequency: • 10mg/oral/daily • Why the medication was ordered this route: • The does was ordered this way because they patient is able to drink the liquid.
In a pharmaceutical setting, many over the counter drugs can usually be classified under one of four main categories: acetyl salicylic acid, acetaminophen, ibuprofen, and naproxen. These four main categories are known as Nonsteroidal Anti-inflammatory Drugs, also known as NSAIDs, which primarily reduce inflammation by reducing the production of prostaglandins. Prostaglandins are the chemicals in the body which promote pain, fever, and inflammation. All of these medicines contain the active pharmaceutical ingredient which is used in order to manufacture a drug product. Most of these medicines also have a coating to make the drug easier to ingest, a colorant, a binder to hold the drug together, caffeine, or a buffering agent to avoid drastic
Hypothesis: If we add pineapple and meat tenderizer to the gelatin, then it will not congeal. Materials needed: Gelatin, Fresh and canned pineapple, Meat tenderizer, Beakers, Cold and boiling water, a timer, 4-5 bowls, 4-5 test tubes and a rack, and a few spoons. STEPS Step 1.
1. Why is gel purification important? What is it used for? Gel-purification is a procedure that yields DNA freed from impurities such as salts, free nucleotides and enzymes, suitable for downstream applications Gel purification is used to recover desired DNA fragments from agarose gels after electrophoretic separation.
Several other pharmaceutical applications depend on its high calcium content (40% elemental calcium) and adsorbing power, especially when used in powders with a high surface area of particles, as well as due to its ability to act as a less expensive filler and
However, typical controlled release formulations are limited by insufficient retention in the stomach. The strategies which are developed to overcome this includes, (a) low density floating DDS b) high density DDS retains in the lower part of the stomach, (c) mucoadhesive delivery systems, (d) swellable which unfolds in the stomach to hinder its escape through the pyloric sphincter. An alternative strategy which combines bioadhesion with the ability to expand by swelling, would be beneficial. This may overcome challenges for oral mucoadhesive systems such as harsh environment of the stomach, which, due to its low pH, results in an inactivation of a wide range of drugs. And also, it prevents the low residence time of the drug at the site of absorption due to wash out effect in the GI tract due to the intestinal motility.
INHALABLE INSULIN Exubera Exubera is a form of administered insulin which was developed by Pfizer and Nektar Therapeutics (California). It was the first inhalable, powdered insulin available and took over eleven years to develop, trial and produce. [19] Most of this research was focused on the stabilisation of the insulin in it’s powdered form which was then to be vaporised in the inhaler. Several compounds were added to the powder in order to stabilise the fine particles including sodium citrate, mannitol, glycine and sodium hydroxide.