Avoid Tablets Research Paper

TABLETS1, 2, 3

Nowadays Novel drug delivery systems (NDDS) has gained more importance in pharmaceutical formulations, because of certain drawbacks with conventional dosage forms and poor patient acceptance. Tablets are having greater importance in the available oral conventional dosage forms.

Tablets are unit solid dosage forms, prepared with the aid of suitable pharmaceutical excipients. They are prepared by compaction or compression of the drug substances with or without diluents. The additives are included in the formulation to enhance the physical appearance, improve stability, aid disintegration and dissolution after administration.

Tablets are mainly classified into

1. Compressed tablets.

2. Moulded tablets.

1. Compressed tablets:

These

Only few technologies can produce tablets that are sufficiently hard and durable to allow them to be packaged in multidose bottles, such as Wowtab® by Yamanouchi-Shaklee, and Durasolv® by CIMA labs.

Hygroscopicity

Several orally disintegrating dosage forms are hygroscopic and cannot maintain physical integrity under normal conditions of temperature and humidity. Hence, they need protection from humidity which requires specialized product packaging.

Amount of drug

The application of technologies used for ODTs is limited by the amount of drug that can be incorporated into each unit dose. For lyophilized dosage forms, the drug dose must be lower than 400 mg for insoluble drugs and less than 60 mg for soluble drugs. This parameter is particularly challenging when formulating a fast-dissolving oral films or wafers.

Aqueous

The formulation is taken orally in the form of uniform dispersion or suspension.

 Many drugs can be formulated in the form of dispersible tablets like β-lactam antibiotic. Dispersible tablets replace the use of conventional type dry syrup dosage form, due to reduction in cost, inventory, improved palatability and stability after reconstitution.

 Dispersible tablets are formulated with an objective of improving the dissolution of poorly soluble drugs by using various disintegrants and super disintegrants available.

 Dispersible tablets are easy and convenient to handle during transport and no risk of breakage of the packaging material. In contrast to suspension where the glass bottles must be handled with care.

 Dispersible tablets can be administered to children conveniently without any swallowing difficulty and is an important factor as dispersible tablets can achieve an exact and required dose.

 Dispersible tablets are well suited for large-scale production. Most dispersible tablets disperse within seconds, though the limit is 3 minutes.

 They have best combined chemical, mechanical and microbiological stability like the other oral forms.

 They can be prepared to be both attractive to the eye and pleasant to